蛭龙活血通瘀对急性脑梗死术后血清炎性因子、血流动力学及术后认知功能的影响

Effects of Zhilong Huoxue Tongyu on serum inflammatory factors,hemodynamics,and postoperative cognitive function in patients with acute cerebral infarction after surgery

目的 观察急性脑梗死(ACI)术后患者经蛭龙活血通瘀胶囊治疗效果,分析其对患者术后认知功能的影响。方法 将患者分为试验组和对照组。对照组为接受常规治疗的ACI术后患者;试验组在对照组治疗的基础上,口服蛭龙活血通瘀胶囊,每次1.6 g,每天3次,均治疗16周。比较2组治疗后的临床疗效;比较2组治疗前后认知功能[蒙特利尔认知预测量表(MocA)]、中医证候积分、炎性因子[C反应蛋白(CRP)、白细胞介素(IL)-6、IL-8]、血流动力学[平均血流速度(V_(m))、搏动指数(PI)];比较2组治疗期间药物不良反应发生情况。结果 对照组75例,试验组63例。治疗后,试验组和对照组的总有效率分别为95.24%(60例/63例)和81.33%(61例/75例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的MocA评分分别为(27.01±1.23)和(24.51±1.63)分,中医证候积分分别为(13.11±2.33)和(16.32±2.11)分,CRP分别为(13.21±2.43)和(16.52±2.63)mg·L^(-1),IL-6分别为(26.56±6.21)和(33.56±6.98)ng·mL^(-1),IL-8分别为(10.35±5.01)和(14.21±5.11)mg·L^(-1),V_(m)分别为(27.46±3.62)和(24.11±3.56)cm·s^(-1),PI分别为1.13±0.22和1.21±0.53,差异均有统计学意义(均P<0.05)。结论 ACI术后患者经蛭龙活血通瘀胶囊治疗,可改善血流动力学,减轻临床症状,提高临床疗效。

Objective To observe the therapeutic effect of Zhilong Huoxue Tongyu capsules on postoperative patients with acute cerebral infarction(ACI),and analyzing its impact on postoperative cognitive function.Methods Patients were divided into treatment group and control group.Control group was given routine treatment,treatment group was given Zhilong Huoxue Tongyu capsules,1.6 g a time,tid,on the basis of control group.All patients were treated for 16 weeks.The clinical efficacy of two groups after treatment was compared;the cognitive function[montreal cognitive prediction scale(Moc A)],traditional Chinese medicine syndrome scores,inflammatory factors[C-reactive protein(CRP),interleukin(IL)-6,IL-8],hemodynamics[mean blood flow velocity(V_(m)),pulsatile index(PI)]between the two groups before and after treatment were compared;the occurrence of adverse drug reactions between the two groups during treatment was compared.Results There were 75 cases in control group and 63 cases in treatment group.After treatment,the total effective rates of treatment group and control group were 95.24%(60 cases/63 cases)and 81.33%(61 cases/75 cases),with statistically significant difference(P<0.05).After treatment,the Moc A scores of treatment group and control group were 27.01±1.23 and 24.51±1.63;the TCM syndrome scores were 13.11±2.33 and 16.32±2.11;the CRPvalues were(13.21±2.43)and(16.52±2.63)mg·L^(-1);IL-6 were(26.56±6.21)and(33.56±6.98)ng·mL^(-1);IL-8 were(10.35±5.01)and(14.21±5.11)mg·L^(-1);V_(m)were(27.46±3.62)and(24.11±3.56)cm·s^(-1);the PI values were 1.13±0.22 and 1.21±0.53,all with statistically significant differences(all P<0.05).Conclusion The treatment of patients after ACI with Zhilong Huoxue Tongyu capsule can improve hemodynamics,alleviate clinical symptoms,and improve clinical efficacy.