造血干细胞移植患儿运动干预最佳证据总结

Summary of best evidence for exercise in children undergoing hematopoietic stem cell transplantation

目的总结造血干细胞移植患儿运动干预的最佳证据,为造血干细胞移植患儿运动干预提供参考。方法依照证据“6S”金字塔模型,计算机检索UpToDate、Cochrane图书馆、PubMed、中国知网等数据库关于造血干细胞移植患儿运动干预的证据。文献检索时限为建库至2023年2月19日。由2名研究者对纳入文献进行质量评价、证据提取和汇总。结果共纳入12篇文献,包括指南3篇、临床决策1篇、专家共识3篇、系统评价3篇、随机对照试验2篇,从运动认知、运动益处、运动管理、运动评估、运动原则、运动处方、运动安全7个方面,共提取25条最佳证据。结论儿童造血干细胞移植期间运动干预的最佳证据为临床实践提供循证依据,建议医护人员充分考虑临床情境,制定更为详细的个性化运动处方。

Objective To summarize the best evidence of exercise intervention in children undergoing Hematopoietic Stem Cell Transplantation(HSCT),so as to provide a reference for implementing exercise intervention in this population.Methods Following the evidence"6S"pyramid model,the relevant literature on exercise in children undergoing HSCT was searched using computer in UpToDate,Cochrane Library,PubMed,CNKI and other databases.The search time interval was from the establishment of each database to February 19,2023.Quality of included literature was evaluated by two researchers,and the evidence was extracted and summarized.Results A total of 12 articles were included:3 guidelines,1 clinical decision supports,3 expert consensus reports,3 systematic reviews and 2 randomized controlled trials.Finally,25 pieces of best evidence from 7 aspects(exercise cognition,exercise benefits,exercise management,exercise evaluation,exercise principles,exercise prescription,exercise safety)were extracted.Conclusion The summarized best evidence on exercise intervention for children undergoing HSCT provides evidence for clinical practice.It is recommended that health professionals should fully consider the clinical situations to develop more detailed personalized exercise prescription.