microRNA调控肿瘤形成相关的因素及信号通路

Factors and Signaling Pathways Related to microRNA Regulation of Tumor Formation

miRNA(microRNA)作为单链非编码RNA,通过结合靶m RNA的非翻译区而抑制蛋白质编码基因的表达。已有研究表明,miRNA可通过ce RNA、外泌体、环境等因素调控肿瘤的形成。绝大多数mi RNA对肿瘤细胞的增殖、凋亡与自噬、细胞周期、细胞的迁移和侵袭以及能量代谢具有调节作用,故mi RNA可作为一种新颖的生物标志物,并已成为肿瘤治疗中极具吸引力的靶点。同时,该文回顾了mi RNA调控肿瘤形成相关的信号通路,并深入讨论了JAK/STAT3、Wnt/β-catenin、PI3K/AKT三种常见的信号通路,旨在为了解肿瘤发生发展的机制提供良好的基础,为发现新的肿瘤治疗途径和肿瘤治疗靶点奠定基础。

miRNA(microRNA)acts as a single-stranded non-coding RNA that inhibits the expression of protein coding genes through binding to the untranslated regions of target mRNA.Previous research has established that miRNA can regulate tumor formation through some factors such as ceRNA,exosomes and environment.The majority of miRNA exhibites regulatory effects on essential processes of tumor cells,including proliferation,apoptosis and autophagy,cell cycle,cell migration and invasion,energy metabolism and so on.Thus,miRNAs has emerged as a promising biomarker for targeted-tumor therapy.This article undertakes an in-depth review of the signaling pathways linked with miRNA regulationg of tumor formation,with a particular focus on the interplay among JAK/STAT3,Wnt/β-catenin and PI3K/AKT pathways.By providing a sound basis for understanding the mechanisms involved in tumor genesis and development,this article aims to lay the groundwork for discovering new tumor treatment pathways and cancer therapy targets.