RNA m6A修饰在子宫内膜癌进展和诊疗评估中的研究现状

Status of RNA m6A modification in the progression,diagnosis and treatment evaluation of endometrial cancer

RNA N6-甲基腺苷(m6A)修饰是一种复杂的表观遗传性修饰,它可以通过3类蛋白[甲基转移酶(写入蛋白)、去甲基转移酶(擦除蛋白)和甲基识别蛋白(阅读蛋白)]来调节真核细胞中RNA的可逆性甲基化修饰。RNA m6A修饰通过影响RNA转录后的剪接、转运、翻译和降解等途径,参与各类生理和病理过程。该文旨在探讨RNA m6A修饰在子宫内膜癌发生、转移和耐药的分子机制及RNA m6A修饰蛋白在子宫内膜癌的诊断预后中的作用。

RNA N6-methyladenosine(m6A)modification is a complex epigenetic modification that could regulate reversible methylation of RNA in eukaryotic cells through three types of proteins:methyltransferases("Writers"),demethyltransferases("Erasers"),and methyl recognition proteins("Readers").RNA m6A modification is involved in various physiological and pathological processes by affecting splicing,transport,translation and degradation of RNA after transcription.The objective of this study was to investigate the molecular mechanism of RNA m6A in the occurrence,metastasis and drug resistance of endometrial cancer and the role of RNA m6A modified protein in the diagnosis and prognosis of endometrial cancer.