昼夜节律紊乱对慢性肾脏病的影响

Circadian rhythm disorder in chronic kidney disease

昼夜节律紊乱可增加包括慢性肾脏病(CKD)、肿瘤、糖尿病、高血压、神经系统疾病和心血管疾病等的患病风险。尽管CKD的治疗取得了长足的进步,但目前CKD仍然是全球的公共卫生问题,也是导致心血管死亡的重要原因,亟需探索新的治疗手段。作为外周生物钟系统主要器官之一,肾脏参与调控机体昼夜节律的形成。本文综述昼夜节律紊乱和CKD之间的联系及相关的干预措施(如生物钟疗法),为CKD的防治提供新的策略。

Circadian rhythm disorder can increase the risk of diseases including chronic kidney disease(CKD),cancers,diabetes,hypertension,neurological diseases and cardiovascular diseases.Although the treatment of CKD has made great progress,CKD remains a global public health problem and an important cause of cardiovascular death.Therefore,it is necessary to explore new treatments.As a major organ of the peripheral clock system,kidney participates in regulating the formation of circadian rhythms.This article reviews the association between circadian rhythm disruption and CKD,and related interventions such as circadian therapeutics,to provide new strategy for the prevention and treatment of CKD.