摘要
沙库巴曲缬沙坦作为结合脑啡肽酶(NEP)抑制剂和血管紧张素受体阻滞剂的双作用药物,经过多项大规模随机临床研究已广泛在慢性心力衰竭和高血压中应用。然而,NEP活性的丧失可以促进β淀粉样蛋白在大脑中的积累,而β淀粉样蛋白沉积是认知功能障碍、阿尔茨海默病的重要发生机制,这引起了众多学者对沙库巴曲缬沙坦副作用的担忧。现回顾NEP抑制剂与其认知功能关系的相关研究,对此做一综述。
As a dual-acting drug binding to neprilysin(NEP)inhibitors and angiotensin receptor blockers,sacubitril/valsartan has been approved for use in chronic heart failure and hypertension after multiple large-scale randomized clinical studies and has been widely used clinically.However,the loss of NEP activity can promote the accumulation of amyloidβ-protein in the brain,and amyloidβ-protein deposition is an important mechanism for cognitive dysfunction and Alzheimer’s disease,which raises concerns about the side effects of sacubitril/valsartan.In this paper,the relationship between NEP inhibitors and their cognitive function is reviewed.
作者
穆耶赛尔·玉苏普
芦颜美
汤宝鹏
Muyassar·Yusup;LU Yanmei;TANG Baopeng(Department of Cardiac Pacing and Electrophysiology,The First Affiliated Hospital of Xinjiang Medical University&Xinjiang Key Laboratory of Cardiac Electrophysiology and Remodeling,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang,China)
出处
《心血管病学进展》
CAS
2023年第8期709-712,共4页
Advances in Cardiovascular Diseases
基金
国家重点专项精准医学项目(2016YFC0900905)。
