糖尿病血管重构作用机制的研究进展

Mechanism of Vascular Remodeling Action in Diabetes Mellitus

糖尿病(DM)是以血葡萄糖水平慢性升高为特征的代谢性疾病,血糖长期控制不佳引发的血管并发症会严重影响预后和患者的生活质量。血管重构是一个动态变化的过程,从一开始的适应性变化进一步发展成为DM血管并发症的病理基础。及时有效地药物干预逆转血管重构将在很大程度上避免DM血管并发症的发生。阐明DM血管重构的作用机制具有重大临床意义,现就DM血管重构涉及的相关机制做一综述,为今后靶向药物筛选和DM血管并发症防治提供新思路。

Diabetes mellitus(DM)is a metabolic disease characterized by a chronic increase in blood glucose levels,and vascular complications arising from poor long-term glucose control can seriously affect the prognosis and the quality of life of patients.Vascular remodeling is a dynamic change process that can further develop from the initial adaptive changes into the pathological basis of vascular complications in DM.Timely and effective pharmacological intervention to reverse vascular remodeling will largely avoid the occurrence of vascular complications in DM.It is of great clinical significance to elucidate the mechanisms involved in DM vascular remodeling,and this article reviews the relevant mechanisms involved in DM vascular remodeling to provide new ideas for future targeted drug screening and prevention of DM vascular complications.