TRIM蛋白家族在心肌缺血再灌注损伤中的研究进展

TRIM Family in Myocardial Ischemia Reperfusion Injury

及时进行血运重建以恢复冠状动脉血流,是急性心肌梗死患者治疗的关键,但血流的突然恢复也会给缺血心肌带来更严重的二次损伤,至今尚未找到治疗心肌缺血再灌注损伤(MIRI)的有效方法。近年的研究发现,三方基序(TRIM)蛋白家族能够介导氧化应激、细胞凋亡及炎症等生物过程,同时还具有调节缺血性处理与促进膜修复的心脏保护功能,在MIRI中起着不可忽视的作用。现就TRIM蛋白家族对MIRI的作用及所涉及的分子调控机制进行综述。

Timely recovery of coronary blood flow is the key treatment for Patients with acute myocardial infarction,but suddenly recovery of blood flow can also cause more serious damage to the ischemic myocardium.The effective treatments of myocardial ischemia reperfusion injury have not been found.Recent research has found that tripartite motif(TRIM)family protein can not only omediate the biological processes of oxidative stress,necrocytosis and inflammation,but also participates in conditioning with cardiac ischemic and membrane repair,which plays an important role in MIRI.In this article,the function of TRIM family proteins in MIRI and the mechanism of molecular regulation are summarized,and focuses on whether TRIM can be used as a new target for anti-MIRI.