中成药六味五灵片在肝病治疗中的研究进展

Research progress of Chinese patent medicine Liuweiwuling tablet in the treatment of liver disease

六味五灵片(Liuweiwuling tablets,LWWL)作为临床治疗慢性乙型肝炎氨基转移酶升高的一线用药,在保肝降酶方面疗效显著。近年来LWWL临床治疗疾病谱逐步扩展,在药物性肝损伤、非酒精性脂肪性肝病、酒精性肝病、病毒性肝炎、肝纤维化等肝病治疗/肝病病理恢复过程中均显示良好的药效。多项基础研究亦对LWWL在肝病方面的药理作用进行了评价,作用机制主要涉及多个免疫相关通路调控。本文将对LWWL在不同肝病的药理作用及机制、临床应用进展以及药效物质进行综述,从而为LWWL对肝脏疾病的临床治疗发挥更大作用提供证据。

Liuweiwuling Tablets(LWWL),as the first-line drug for the treatment of chronic hepatitis B(CHB)with elevated aminotransferase,has a significant effect on liver protection and enzyme reduction.In recent years,with the expansion of its clinical treatment spectrum,it has been found that LWWL has good efficacy in liver disease such as drug-induced liver injury(DILI),nonalcoholic fatty liver disease(NAFLD),and alcoholic liver disease(ALD),viral liver disease,and liver disease pathologic processes such as liver fibrosis.A number of basic studies have also evaluated the pharmacological effects of LWWL in liver diseases,and the mechanism of action mainly involves the regulation of several immune-related pathways.We will review the pharmacological roles and mechanisms of LWWL in different liver diseases,the progress of clinical application,and the pharmacodynamic agents,so as to provide solid evidence for the greater role of LWWL in liver diseases.