孕三烯酮联合醋酸亮丙瑞林治疗对子宫内膜异位症患者生殖激素水平、子宫动脉血流参数以及妊娠率的影响

Effect of pregnant trienone combined with leuprolide acetate treatment on reproductive hormone levels,uterine artery flow parameters,and pregnancy rate in patients with endometriosis

目的研究孕三烯酮联合醋酸亮丙瑞林治疗对子宫内膜异位症患者的效果,及其对生殖激素水平、子宫动脉血流参数以及妊娠率的影响。方法选取2019年6月~2021年12月新疆医科大学第一附属医院所符合患有子宫内膜异位症标准的128例患者,按照治疗方案均分为对照组(孕三烯酮治疗)、观察组(在对照组基础上联合使用醋酸亮丙瑞林),均治疗6个月。对比两组生殖激素水平、子宫动脉血流参数以及妊娠率等情况。结果观察组用药疗效(96.88%)显著高于对照组(68.75%),且观察组的症状复发率(3.13%)显著低于对照组(14.06%),差异有统计学意义(P<0.050)。治疗后,观察组的实际妊娠例数显著高于对照组,差异有统计学意义(P=0.044);观察组动脉血流灌注指数(Perfusionindex,PI)、阻力指数(Resistanceindex,RI)明显低于对照组,差异有统计学意义(P=0.000)。两组治疗后促卵泡生成激素、促黄体生成激素、雌二醇均降低,且观察组比对照组高,差异有统计学意义(P=0.000)。观察组的不良反应(18.8%),明显低于对照组(84.4%),差异有统计学意义(P<0.010)。结论孕三烯酮与醋酸亮丙瑞林联合使用对于子宫内膜异位症的治疗更为有效,并且可以相对减少机体的不良反应,有效抑制了子宫内膜异位症的复发及增加机体的妊娠率。

Objective To study the effect of progesterone combined with leuprolide acetate therapy on patients with endometriosis and its effect on reproductive hormone levels,uterine artery blood flow parameters and pregnancy rate.Methods One hundred and twenty-eight patients who met the criteria for endometriosis in our hospital from June 2019 to December 2021 were used for the study,and were divided into a control group(treated with progesterone)and an observation group(treated with leuprolide acetate in combination with the control group)according to a randomized,double-blind method,both of which were treated for 6 months.The reproductive hormone levels,uterine artery blood flow parameters and pregnancy rate were observed in both groups.Results The efficacy of medication in the observation group(96.88%)was significantly higher than that in the control group(68.75%),while the recurrence rate of symptoms in the observation group(3.13%)was significantly lower than that in the control group(14.06%)(P<0.050);after treatment,the actual number of pregnancy cases in the observation group was significantly higher than that in the control group(P=0.044);the RI and PI in the observation group were significantly lower than those in the control group,which was statistically significant.The folliculogenic hormone luteinizing hormone and estradiol were lower in the 2 groups after treatment,and the difference was statistically higher in the observation group than in the control group(P=0.000).The adverse effects in the observation group(18.8%)were significantly lower than in the control group(84.4%)(P<0.010).Conclusion The combination of progesterone and leuprolide acetate is more effective in the treatment of endometriosis and can relatively reduce the side effects of the organism,effectively inhibit the recurrence of endometriosis and increase the pregnancy rate of the organism.