胶质母细胞瘤电场治疗相关头皮不良反应预防方案的制订及应用

Formulation and application of prevention scheme for scalp adverse reactions related to electric field treatment of glioblastoma

目的:制定胶质母细胞瘤电场治疗相关头皮不良反应预防方案,探讨临床应用效果。方法:采取类试验研究设计,将2019年07月至2020年12月行肿瘤电场治疗的胶质母细胞瘤患者38例纳入对照组,按照常规头皮管理方案进行干预;将2021年01月至2022年07月的40例患者纳入观察组,在对照组基础上实施胶质母细胞瘤电场治疗相关头皮不良反应预防管理方案。比较佩戴电场设备6周后相关皮肤不良事件等级(dermatological adverse event,dAE)、佩戴电场设备3个月后健康相关生活质量及治疗依从性。结果:佩戴电场设备6周后观察组1级、2级、3级dAE发生率均低于对照组。观察组治疗后QLQ-C30量表总体健康评分高于对照组(P<0.05);疼痛、疲倦、恶心呕吐、食欲下降、腹泻、便秘、失眠、角色评分均低于对照组(P<0.05);情绪、认知评分均高于对照组(P<0.05);两组患者社会、经济影响、呼吸困难、躯体评分比较无显著差异(P>0.05);观察组佩戴电场设备期间治疗依从性均高于对照组(P<0.05)。结论:胶质母细胞瘤电场治疗相关头皮不良反应预防管理方案的制定及实施可有效降低电场相关头皮dAE,提高治疗依从性,改善生活质量。

Objective:To formulate the prevention plan of scalp adverse reactions related to electric field treatment of glioblastoma and explore the clinical application effect.Methods:38 patients with glioblastoma treated by tumor electric field from July 2019 to December 2020 were included in the control group and intervened according to the routine scalp management plan.40 patients from January 2021 to July 2022 were included in the observation group,and the control group was given the prevention and management plan of scalp adverse reactions related to electric field treatment of glioblastoma.The dermatological adverse event(dAE)after wearing electric field equipment for 6 weeks,health-related quality of life and treatment compliance after wearing electric field equipment for 3 months were compared.Results:After wearing electric field equipment for 6 weeks,the incidence of grade 1,grade 2 and grade 3 dAE in the observation group was lower than that in the control group.After treatment,the overall health score of QLQ-C30 in the observation group was higher than that in the control group(P<0.05).Pain,fatigue,nausea and vomiting,loss of appetite,diarrhea,constipation,insomnia and role score were all lower than those in the control group(P<0.05).The scores of emotion and cognition were higher than those of the control group(P<0.05).There was no significant difference in social and economic influence,dyspnea and body score between the two groups(P>0.05).The treatment compliance of the observation group was higher than that of the control group(P<0.05).Conclusion:The development and implementation of the protocol for the prevention and management of scalp adverse events related to glioblastoma field therapy can effectively reduce the grade of scalp adverse events related to electric field therapy,improve treatment compliance and quality of life.