纳米氧化铈抗蒽环类药物心肌损伤作用机制研究进展

Research Progress on the Mechanism of Cerium Oxide Nanoparticles Against Anthracyclines Myocardial Injury

蒽环类药物产生的剂量依赖性心脏毒性限制了其在肿瘤治疗中的深入应用。最新的动物实验研究表明,纳米氧化铈协同蒽环类药物可以提高其化疗疗效而不增加心脏正常细胞的损伤。本文通过对纳米氧化铈的生物医学性能和蒽环类药物心脏毒性的相关机制进行介绍,就纳米氧化铈在蒽环类药物心脏毒性中的抗氧化应激和抗细胞凋亡作用进行综述,为临床上防治蒽环类药物心脏毒性提供一种可能的策略。

Dose-dependent cardiotoxicity of anthracyclines limits its further use in cancer therapy.Recent animal studies have shown that cerium oxide nanoparticles in conjunction with anthracyclines can improve the efficacy of chemotherapy without increasing the damage to normal heart cells.This article introduces the biomedical properties of cerium oxide nanoparticles and the related mechanisms of cardiotoxicity of anthracyclines,and reviews the anti-oxidative stress and anti-apoptosis effects of cerium oxide nanoparticles in the cardiotoxicity of anthracyclines,so as to provide a possible strategy for clinical prevention and treatment of anthracyclines cardiotoxicity.