热毒宁注射液联合更昔洛韦治疗小儿传染性单核细胞增多症的疗效

Efficacy of Reduning Injections combined with ganciclovir in the treatment of infectious mononucleosis in children

目的探究热毒宁注射液联合更昔洛韦静脉给药治疗小儿传染性单核细胞增多症(infectious mononucleosis,IM)的疗效。方法选取近3年就诊的106例IM患儿,用随机数字表法分为观察组(热毒宁注射液联合更昔洛韦静脉给药)和对照组(更昔洛韦静脉给药),每组53例。比较2组患儿的临床恢复情况(体温恢复时间、淋巴结缩小时间及咽峡炎缓解时间);比较2组治疗前后的心肌酶[肌酸激酶同工酶(creatine kinase isoenzyme,CK-MB)、肌酸激酶(creatine kinase,CK)和乳酸脱氢酶(lactate dehydrogenase,LDH)]、血清炎症因子[降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)及白细胞介素-6(interleukin-6,IL-6)]及血常规检查指标[白细胞计数(white blood cell count,WBC)、血沉(erythrocyte sedimentation rate,ESR)、异型淋巴细胞百分比]水平;记录2组用药不良反应。结果观察组患儿的体温恢复时间、淋巴结缩小时间及咽峡炎缓解时间较对照组明显缩短(P<0.05);治疗后,2组血清CK-MB、CK及LDH水平均明显降低,且观察组低于对照组(P<0.05);治疗后,2组血清炎症因子(PCT、CRP及IL-6)及血常规指标(WBC、ESR、异型淋巴细胞百分比)均明显降低,且观察组低于对照组(P<0.05);治疗期间观察组出现不良反应6例、对照组出现4例,组间比较差异无统计学意义(P>0.05)。结论热毒宁注射液联合更昔洛韦静脉给药治疗IM可缓解炎性症状、调节心肌酶及血常规指标水平,促进患者病情恢复。

Objective To explore the efficacy of Reduning Injections combined with ganciclovir intravenous administration in the treatment of infectious mononucleosis(IM)in children.Methods 106 children with IM were selected in the past 3 years and divi-ded into observation group(Reduning Injections combined with ganciclovir intravenous administration,n=53)and control group(ganciclovir intravenous administration,n=53)by the random number table method.The clinical recovery status(body temperature recovery time,lymph node shrinkage time and angina remission time),the levels of myocardial enzymes[creatine kinase isoenzyme(CK-MB),creatine kinase(CK)and lactate dehydrogenase(LDH)],the serum inflammatory factors[procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)]and the blood routine examination indicators[white blood cell count(WBC),erythrocyte sedimentation rate(ESR)and percentage of atypical lymphocytes]before and after treatment were compared between the 2 groups.Adverse drug reactions were recorded in the 2 groups.Results The body temperature recovery time,lymph node shrinkage time and angina remission time in observation group were significantly shorter than those in control group(P<0.05).The serum levels of CK-MB,CK and LDH in both groups after treatment were significantly decreased compared with those before treatment,and the levels in observation group were lower than those in control group(P<0.05).After treatment,the le-vels of serum inflammatory factors(PCT,CRP and IL-6)and blood routine indicators(WBC,ESR and percentage of atypical lymphocytes)were significantly declined in the 2 groups than those before treatment,and the above levels in observation group were lower than those in control group(P<0.05).There were 6 cases of adverse reactions in observation group and 4 cases in control group during treatment,there was no statistically significant difference between the 2 groups(P>0.05).Conclusion Reduning Injections combined with ganciclovir intravenous administration in the treatment of infantile IM can relieve inflammatory symptoms,regulate myocardial enzymes and blood routine indicators,and promote recovery.