中药对氨基糖苷类药物和顺铂致耳毒性的抑制研究进展

Research inhibitive on the inhibitive mechanism of traditional Chinese medicine against aminoglycoside and cisplatin-induced ototoxicity

目的探究中药预防氨基糖苷类药物和顺铂致耳毒性机制的共同点,为抑制耳毒性中药的研发提供依据。方法应用CNKI和PubMed数据库,查阅2012—2022年相关文献,以氨基糖苷、顺铂、耳毒性等为检索词,概述当前氨基糖苷类药物和顺铂诱发耳毒性的研究现状,进一步对预防氨基糖苷类药物和顺铂致耳毒性的中药单体化合物和中成药进行系统梳理,并归纳其共同作用机制。结果发现16个中药单体化合物和4味中成药通过抗氧化、抗炎症、抑制钙离子超载和一氧化氮过量生成等间接途径抑制细胞凋亡,或通过直接抑制凋亡蛋白表达抑制细胞凋亡,发挥耳保护作用。结论中药在预防氨基糖苷类药物和顺铂致耳毒性中具有重要的作用,为后续开发基于靶点的耳毒性中药提供重要的依据。

Objective In order to provide a basis for the research and development of traditional Chinese medicines(TCMs)for ototoxicity-inhibition,the commonalities in the mechanisms of ototoxicity prevention of aminoglycosides and cisplatin drugs in TCMs are investigated.Methods Using CNKI and PubMed databases,we reviewed the literature from 2012 to 2022,using aminoglycosides,cisplatin and ototoxicity as search terms to outline the current research status of ototoxicity induced by aminoglycosides and cisplatin drugs,and further to systematically sort out the Chinese monomer compounds and proprietary Chinese medicines with preventive effects on aminoglycosides and cisplatin ototoxicity,and to summarize their common mechanisms of action.Results It was found that 16 TCM monomer compounds and 4 Chinese patent medicines inhibit apoptosis through indirect pathways such as antioxidant,anti-inflammatory,the inhibition of calcium ions overload and excessive nitric oxide production,or inhibit apoptosis by directly inhibiting the expression of apoptotic proteins.Conclusion TCMs have an important effect in preventing the ototoxicity induced by aminoglycosides and cisplatin drugs.This article provides an important basis for the subsequent development of target-based TCM for ototoxicity inhibition.