127例幽门螺杆菌感染与牙周炎的相关性分析

Correlation analysis between Helicobacter pylori infection and periodontitis in 127 cases

目的对127例幽门螺杆菌感染情况及牙周状况进行调查,分析牙周炎、口腔幽门螺杆菌和胃幽门螺杆菌三者之间的相关性。方法将2021年12月—2022年6月于南通市中医院或南通市第三人民医院采用C14-尿素呼气试验方法检测胃幽门螺杆菌者,按照纳入排除标准并遵循自愿参与原则,纳入127例填写调查问卷并进行口腔幽门螺杆菌检测及牙周状况检查。应用统计SPSS 20.0软件分析数据。结果127例患者中口腔幽门螺杆菌与胃幽门螺杆菌感染相关(P<0.05),口腔幽门螺杆菌感染与牙周状况亦具有关联性(P<0.05),中重度牙周炎患者与非中重度牙周炎者相比,胃幽门螺杆菌感染率有增高趋势,但尚无统计学差异(P>0.05)。总人群的多元Logistic回归结果提示:口腔幽门螺杆菌是胃幽门螺杆菌感染的危险因素。结论口腔幽门螺杆菌与胃幽门螺杆菌感染密切关联,中重度牙周炎可增加幽门螺杆菌的感染率。

Objective To analyze the correlation among periodontitis,oral and gastric Helicobacter pylori by investigating the infection of Helicobacter pylori and periodontal status in 127 patients.Methods From December 2021 to June 2022,127 cases of pa⁃tients who were tested for gastric Helicobacter pylori by 14C⁃urea breath test in Nantong Hospital of Traditional Chinese Medicine or The third People's Hospital of Nantong,were included to fill out the questionnaire and tested for oral Helicobacter pylori and periodontal ex⁃amination,according to the inclusion and exclusion criteria and following the principle of voluntary participation.Statistical SPSS 20.0 software was used to analyze the data.Results Oral and gastric Helicobacter pylori infections were correlated in 127 patients(P<0.05).Oral Helicobacter pylori infection was also associated with periodontal status(P<0.05).The infection rate of gastric Helicobacter pylori in patients with moderate to severe periodontitis tended to increase,but the difference was not statistically significant(P>0.05).Multivariate Logistic regression analysis of the total population suggested that oral Helicobacter pylori was a risk factor for gastric Helico⁃bacter pylori infection.Conclusion The infection rate of oral Helicobacter pylori is closely related to the infection rate of gastric Helico⁃bacter pylori.Moderate to severe periodontitis can increase the infection rate of Helicobacter pylori.