基于CiteSpace文献计量法的孕妇碘营养领域研究热点分析

Analysis of research hotspots of iodine nutrition in pregnant women based on CiteSpace bibliometric method

目的了解孕妇碘营养领域的研究现状,探测孕妇碘营养领域的研究热点和未来趋势。方法以"孕妇"和"碘"为检索词,对中国知网(CNKI)数据库、万方数据库和中华医学期刊全文数据库中2000年1月至2021年12月收录的孕妇碘营养相关文献进行检索,采用CiteSpace 6.2.2.0软件梳理论文发表情况、核心作者以及研究热点等。结果共纳入有效文献879篇,2000-2017年发文量总体呈上升趋势,在2017年后有所回落。在879篇文献中,第一作者为核心作者(M≈3)的有29人,共发表文献109篇,占总文献数的12.40%;已形成多个合作关系相对稳定的研究群体,以天津医科大学陈祖培、张万起等的合作团队规模较大。关键词共现分析显示,孕妇、尿碘、碘营养为高频关键词;中介中心性(Centrality)>0.07的关键词依次为孕妇(0.48)、妊娠(0.40)、尿碘(0.37)、碘缺乏病(0.25)、碘营养(0.20)、甲状腺(0.12)、甲状腺素(0.10)、婴幼儿(0.09)。突现词分析结果显示,孕妇碘营养研究主题演变大致为2000-2011年的新生儿、婴幼儿等重点人群碘营养监测结果研究,2012-2016年的妊娠期甲状腺素参考值范围等研究,2017-2021年的碘盐浓度调整后孕妇和儿童碘营养状况变化。聚类结果显示,355个关键词共聚合得出10个聚类群,聚类平均轮廓值(Silhouette)>0.8,聚类结果较为合理;研究主题可分为重点人群碘营养及甲状腺肿监测结果、妊娠期甲状腺激素及妊娠结局、甲状腺相关疾病的研究三大类。结论碘元素对孕妇及后代健康具有重要作用,应密切关注孕妇碘营养状况的变化,针对目前呈现出的新变化趋势,应该开展多学科合作,共同促进孕妇碘营养适宜。

Objective To study the current status of research in the field of iodine nutrition for pregnant women and to detect the hot spots and future trends in the field of iodine nutrition for pregnant women.Methods Using"pregnant women"and"iodine"as search terms,we searched the literature related to iodine nutrition in pregnant women from January 2000 to December 2021 in China Knowledge Network(CNKI)database,Wanfang database and Chinese Medical Journal Full Text Database.CiteSpace 6.2.2.0 software was used to sort out the publication status,core authors and research hotspots of the papers.Results A total of 879 valid papers were included,with an overall number of publications increasing trend from 2000-2021 and a decline after 2017.Among the 879 papers,29 first authors were core authors(M~3),and 109 papers were published,accounting for 12.40%of the total literature;several research groups with relatively stable collaborative relationships had been formed,with the larger collaborative team of Chen Zupei and Zhang Wanqi at Tianjin Medical University.Keyword co-occurrence analysis showed that pregnant women,urinary iodine,and iodine nutrition were high-frequency keywords;keywords with mediated centrality>0.07 were pregnant women(0.48),pregnancy(0.40),urinary iodine(0.37),iodine deficiency disorders(0.25),iodine nutrition(0.20),thyroid(0.12),thyroxine(0.10),infants and children(0.09).The analysis of the emergent words showed that the evolution of iodine nutrition research themes in pregnant women was broadly based on studies of iodine nutrition monitoring results in key populations such as newborns and infants from 2000-2011,studies such as the range of thyroxine reference values during pregnancy from 2012-2016,and changes in iodine nutrition status of pregnant women and children after adjustment of iodized salt concentration from 2017-2021.The clustering results showed that a total of 355 keywords were aggregated to yield 10 clusters,and the average profile value of clusters(Silhouette)>0.8,which was a reasonable clustering result;the study topics can be divided into three major categories,iodine nutrition and goiter monitoring results in key populations,thyroid hormones and pregnancy outcomes during pregnancy,and studies on thyroid-related diseases.Conclusions Iodine plays an important role in the health of pregnant women and their offspring,and changes in the iodine nutrition status of pregnant women should be closely monitored.In response to the new trends of change that are currently present,multidisciplinary cooperation should be developed to respond to social concerns and jointly promote the maintenance of iodine nutrition in pregnant women at appropriate levels.