肿瘤切除手术诱发术后复发的机制及纠正策略研究进展

Research progress on mechanism and correction strategy of tumor recurrence promoted by resection

手术切除是多数肿瘤治疗的基础策略,复发和转移是恶性肿瘤手术治疗失败的主要原因。临床上多种类型的肿瘤患者会在术后1~2年内出现复发风险,导致复发事件高发。尽管目前手术治疗手段已经取得极大进步,仍无法完全避免肿瘤患者术后复发。本文主要从激活交感神经系统、凝血系统、激发炎症、诱导免疫抑制等方面介绍手术切除诱发肿瘤复发转移机制的复杂性,并围绕这些机制介绍相关纠正策略,为提升肿瘤手术治疗效率提供重要参考,也为术后复发纠正策略的设计提供启发。

Surgery is a mainstay treatment for patients with solid tumors.However,recurrence and metastasis remain the major reasons why surgical treatment for malignant tumors can fail.Clinically,patients with various tumor types are most susceptible to recurrence within one to two years post-surgery,resulting in a significantly high incidence of recurrence events.Despite significant progress in surgical treatment,tumor recurrence following surgery cannot be entirely prevented.This paper delves into the complexity of the mechanism wherein surgical resection promotes tumor recurrence and metastasis by examining the activation of the sympathetic nervous system and coagulation system,the stimulation of inflammation,and the induction of immune suppression.The paper also introduces relevant corrective strategies based on these mechanisms.These findings not only serve as an essential reference for enhancing the efficacy of tumor surgical treatment,but also provide insights for designing postoperative relapse correction strategies.