多囊卵巢综合征患者行体外受精-胚胎移植前药物预处理的研究进展

Progress of Pharmacological Pretreatment Before in Vitro Fertilization-Embryo Transfer in Patients with Polycystic Ovarian Syndrome

多囊卵巢综合征(PCOS)是女性常见的生殖内分泌代谢性疾病。部分PCOS患者因不孕需行体外受精-胚胎移植(IVF-ET)助孕。文献报道,PCOS患者在IVF助孕后发生卵巢过度刺激综合征、流产、极早产、妊娠期糖尿病和妊娠期高血压疾病的风险显著增加。在IVF助孕前给予药物预处理可能是改善PCOS患者妊娠结局的有效手段。本文对相关研究进行综述后发现,采用口服避孕药、二甲双胍、肌醇、生长激素或维生素D预处理,或在控制性促排卵期间应用前述药物,能改善PCOS患者的IVF结局。

Polycystic ovarian syndrome(PCOS)is a common female disorder with reproductive,endocrine and metabolic features.Women with PCOS and anovulatory infertility could be offered in vitro fertilization-embryo transfer(IVF-ET)as fertility treatment.A significantly increased risk of ovarian hyperstimulation syndrome,miscarriage,very preterm delivery,gestational diabetes mellitus and hypertensive disorders has been reported to be associated with PCOS in women undergoing IVF.Pharmacological pretreatment before IVF may improve pregnancy outcomes in patients with PCOS.According to review,it is found that preconditioning with oral contraceptives,metformin,inositol,growth hormone,or vitamin D,or during controlled ovulation,could improve IVF outcomes in patients with PCOS.