基于炎症因子及Th17、Treg探讨布地格福治疗哮喘合并慢阻肺的临床价值

Based on the Inflammatory Factors,Th17 and Treg,to Explore the Clinical Value of Budigefl in the Treatment of Asthma Combined with COPD

目的探讨布地格福治疗哮喘合并慢性阻塞性肺疾病(以下称“慢阻肺”)对患者炎症因子及辅助性T细胞17(Th17)、调节性T细胞(Treg)水平的影响。方法选取2020年5月至2022年5月我院收治的78例哮喘合并慢阻肺患者,按随机数表法分为两组,各39例。对照组予以布地奈德福莫特罗吸入治疗,观察组予以布地格福吸入治疗,持续4周。比较两组临床疗效、炎症因子水平、Th17水平、Treg水平及不良反应。结果观察组总有效率为94.87%(37/39),高于对照组的79.49(31/39);观察组治疗后肿瘤坏死因子-α(TNF-α)(65.38±5.27)pg/mL、白介素-6(IL-6)(9.52±1.17)pg/mL及C反应蛋白(CRP)(5.36±1.12)mg/L,低于对照组的(70.41±5.32)pg/mL、(11.47±1.25)pg/mL、(7.58±1.14)mg/L,差异有统计学意义(P<0.05);观察组治疗后Th17(3.25±0.37)%低于对照组(4.19±0.42)%,Treg(3.42±0.36)%高于对照组(2.69±0.32)%,差异有统计学意义(P<0.05);两组均无严重不良反应,差异无统计学意义(P>0.05)。结论布地格福治疗哮喘合并慢阻肺,可提高疗效,加快炎症反应消退,纠正Th17、Treg水平异常,安全可靠。

Objective To investigate the effect of budigefl treatment on asthma combined with COPD on the levels of inflammatory factors and adjuvant T cells 17(Th17)and regulatory T cells(Treg).Methods Se-lected 78 patients with COPD admitted to our hospital from May 2020 to May 2022.The control group was treated with budeseidford motero inhalation,and the observation group received budeseefl inhalation therapy for 4 weeks.The clinical efficacy,levels of inflammatory factors,Th17,Treg levels,and adverse effects were com-pared in the two groups.Results The total response rate 94.87%(37/39)was higher than the control group 79.49(31/39),Post-treatment tumor necrosis factor-α(TNF-α)(65.38±5.27)pg/mL,interleukin-6(IL-6)(9.52±1.17)pg/mL and C reactive protein(CRP)(5.36±1.12)mg/L were lower than the control group(70.41±5.32)pg/mL,(11.47±1.25)pg/mL,(7.58±1.14)mg/L,Statistical difference(P<0.05);In the observation group,the Th17(3.25±0.37)%was lower than that of the control group(4.19±0.42)%,The Treg(3.42±0.36)%was higher than that in the control group(2.69±0.32)%,Statistical difference(P<0.05);Neither group had any serious adverse effects(P>0.05).Conclusion Budigefl can improve the ef-ficacy of asthma in patients with COPD,accelerate the resolution of inflammation,and correct the abnormal Th17 and Treg levels safely.