基于氧化应激探讨中药活性成分干预蒽环类药物心脏毒性机制研究进展

Research Progress on the Prevention and Treatment of Anthracycline Cardiotoxicity by Active Components of Traditional Chinese Medicine Based on Oxidative Stress

从氧化应激角度对中药活性成分防治蒽环类药物心脏毒性作用机制的研究进行总结,以期为蒽环类药物心脏毒性的防治与进一步药物开发提供参考。中药活性成分主要通过保护线粒体功能、抑制铁死亡、抗硝基氧化应激、调控还原型辅酶Ⅱ(NADPH)氧化酶、增强抗氧化防御、抗脂质过氧化等机制,以及调控Nrf2、AMPKα、SIRT、UCP、Bmi-1等多个信号因子来减轻蒽环类药物心脏毒性。

From the perspective of oxidative stress,this paper summarizes the research on the mechanism of action of the active ingredients of traditional Chinese medicine to prevent and treat the cardiotoxicity of anthracycline drugs,in order to provide reference for the prevention and treatment of ANT cardiotoxicity and further drug development.According to the analysis of relevant documents in recent years,the active ingredients of traditional Chinese medicine can protect mitochondrial function,inhibit iron death,resist nitro oxidative stress,regulate NADPH oxidase,enhance antioxidant defense,resist lipid peroxidation,and regulate Nrf2,AMPKα,SIRT,UCP,Bmi-1 and other signal factors to reduce the cardiotoxicity of ANT.