基于痰瘀生风理论探讨动脉粥样硬化与线粒体自噬的相关性

The Relationship between Mitophagy and Atherosclerosis Based on the Theory of Phlegm and Blood Stasis Causing Wind

近年来从线粒体自噬角度治疗动脉粥样硬化越来越受到重视。中医学认为动脉粥样硬化的病理变化属于本虚标实,与痰瘀生风理论密切相关。线粒体自噬可清除受损的线粒体、促进线粒体更新,就如中医搜风祛痰治法。从中医痰瘀生风理论出发,探讨线粒体自噬与动脉粥样硬化的关系,为临床治疗动脉粥样硬化性疾病提供理论基础。

In recent years,more and more attention has been paid to the treatment of atherosclerosis from the perspective of mitophagy.Traditional Chinese medicine believes that the pathological changes of atherosclerosis belong to deficiency in origin and excess in superficislity,which is closely related to the theory of phlegm and blood stasis causing wind.Mitophagy can remove damaged mitochondria and promote mitochondrial renewal,just like the traditional Chinese medicine treatment of wind-dispelling phlegm.This paper discusses the relationship between mitophagy and atherosclerosis based on the theory of phlegm and blood stasis causing wind,so as to provide a theoretical basis for clinical treatment of atherosclerotic diseases.