桑菊饮加减联合孟鲁司特治疗小儿咳嗽的效果

Effect of Sangju Decoction Modified Combined with Montelukast in the Treatment of Infantile Cough

目的:探讨桑菊饮加减联合孟鲁司特治疗小儿咳嗽的效果。方法:选择2021年5月-2022年6月广州中医药大学第一附属医院白云医院收治的小儿咳嗽患者100例为研究对象,根据随机数表法分为两组,各50例。对照组采用孟鲁司特钠咀嚼片治疗,观察组在对照组基础上联合桑菊饮加减治疗,两组均治疗14 d。比较两组临床疗效、症候积分、C反应蛋白(CRP)、降钙素原(PCT)、白细胞计数(WBC)、血小板计数及不良反应发生率。结果:观察组治疗总有效率为96.00%,高于对照组的84.00%,差异有统计学意义(P<0.05)。治疗14 d后,两组咳嗽、咳痰、鼻塞、流涕及咽充血等症候积分均低于治疗前,且观察组上述指标积分均低于对照组,差异有统计学意义(P<0.05)。治疗14 d后,两组CRP、PCT、WBC和血小板计数均低于治疗前,且观察组上述指标均低于对照组,差异有统计学意义(P<0.05)。两组腹痛、腹泻、皮肤过敏、恶心呕吐及肝肾异常等不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:桑菊饮加减联合孟鲁司特治疗小儿咳嗽能提高临床效果,降低症候积分和CRP、PCT等生化指标水平,且药物安全性较高。

Objective:To explore the effect of Sangju Decoction modified combined with Montelukast in the treatment of infantile cough.Method:A total of 100 patients with infantile cough from Baiyun Hospital of the First Affiliated Hospital of Guangzhou University of Chinese Medicine from May 2021 to June 2022 were selected as the study subjects.According to the random number table method,they were divided into two groups,with 50 cases in each group.The control group was treated with Montelukast Sodium Chewable Tablets,and the observation group was treated with Sangju Decoction modified on the basis of the control group.Both groups were treated for 14 d.The clinical efficacy,symptom score,C-reactive protein(CRP),procalcitonin(PCT),white blood cell count(WBC),platelet and adverse reaction rate were compared between the two groups.Result:The total effective rate of the observation group was 96.00%,which was higher than 84.00%in the control group,the difference was statistically significant(P<0.05).After 14 d of treatment,the scores of symptoms such as cough,expectoration,nasal congestion,runny nose,and pharyngeal congestion in both groups were lower than those before treatment,and the scores of the above indicators in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).After 14 d of treatment,CRP,PCT,WBC,and platelet count in both groups were lower than those before treatment,and the above indicators in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions such as abdominal pain,diarrhea,skin allergies,nausea and vomiting,and liver and kidney abnormalities between the two groups(P>0.05).Conclusion:Sangju Decoction modified combined with Montelukast can improve the clinical efficacy of infantile cough,reduce the symptom score,CRP,PCT and other biochemical indicators,and the drug safety is high.