盐酸氨基葡萄糖联合塞来昔布治疗膝骨关节炎的效果

Effect of Glucosamine Hydrochloride Combined with Celecoxib in the Treatment of Knee Osteoarthritis

目的:分析盐酸氨基葡萄糖联合塞来昔布治疗膝骨关节炎的效果。方法:选取2019年8月-2020年8月简阳市人民医院收治的450例膝骨关节炎患者。按照治疗方式的不同将其分为对照组(n=200)和观察组(n=250),对照组给予塞来昔布治疗,观察组给予盐酸氨基葡萄糖联合塞来昔布治疗。比较两组临床疗效、不良反应发生情况及治疗前、治疗2个月后的西安大略和麦克马斯特大学(WOMAC)骨关节炎指数评分、日常生活活动能力(ADL)评分及炎症因子水平。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗前,两组炎症因子水平比较,差异无统计学意义(P>0.05);治疗2个月后,观察组白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、白细胞介素-18(IL-8)水平均低于对照组,差异有统计学意义(P<0.05)。治疗前,两组WOMAC骨关节炎指数评分、ADL评分比较,差异无统计学意义(P>0.05);治疗2个月后,观察组WOMAC骨关节炎指数评分低于对照组,ADL评分高于对照组,差异有统计学意义(P<0.05)。结论:对于膝骨关节炎患者而言,对其实施盐酸氨基葡萄糖联合塞来昔布治疗的效果更好,可抑制炎症反应,提高患者膝关节功能及生活质量,且不增加不良反应。

Objective:To analyze the effects of Glucosamine Hydrochloride combined with Celecoxib in the treatment of knee osteoarthritis.Method:A total of 450 patients with knee osteoarthritis admitted to the People's Hospital of Jianyang City from August 2019 to August 2020 were selected.According to the different treatment methods,they were divided into the control group(n=200)and the observation group(n=250),the control group was treated with Celecoxib,and the observation group was treated with Glucosamine Hydrochloride combined with Celecoxib.The clinical efficacy,adverse reactions,Western Ontario and McMaster University(WOMAC)osteoarthritis index score,activities of daily living(ADL)score and inflammatory factor levels before and after 2 months of treatment between the two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there were no statistically significant differences in the levels of inflammatory factors between the two groups(P>0.05).After 2 months of treatment,the levels of interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-18(IL-18)in the observation group were significantly lower than those of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in WOMAC osteoarthritis index score and ADL score between the two groups(P>0.05).After 2 months of treatment,the WOMAC osteoarthritis index score of the observation group was lower than that of the control group,and the ADL score was higher than that of the control group,the differences were statistically significant(P<0.05).Conclusion:For patients with knee osteoarthritis,the effect of Glucosamine Hydrochloride combined with Celecoxib is better,which can inhibit inflammatory reaction,improve the knee joint function and quality of life of patients,without increasing adverse reactions.