比索洛尔联合常规治疗对慢性阻塞性肺疾病合并心血管疾病的影响

Effect of Bisoprolol Combined with Conventional Treatment on Chronic Obstructive Pulmonary Disease Complicated with Cardiovascular Disease

目的:探讨比索洛尔联合常规治疗对慢性阻塞性肺疾病(C0PD)合并心血管疾病(CVD)的影响。方法:选取2019年1月-2022年1月漳州古雷港经济开发区第一医院收治的80例COPD合并CVD患者。根据随机数表法将其分为对照组和研究组,各40例。对照组给予常规治疗,研究组在对照组基础上给予富马酸比索洛尔片。比较两组治疗前后肺功能、呼吸困难情况、运动耐力、生活质量及急性加重再住院、不良心血管事件及死亡率。结果:治疗后,研究组血氧饱和度、第1秒用力呼气容积/用力肺活量(FEV_(1)/FVC%)、每分钟最大通气量、6分钟步行试验距离均高于对照组,呼吸频率、呼吸BORG疲劳指数评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组总体健康、精神健康、情感职能、生理职能、生理功能、社会功能评分较治疗前提升,研究组总体健康、精神健康、情感职能、生理职能、生理功能、社会功能评分均高于对照组,差异有统计学意义(P<0.05)。研究组急性加重再住院率、不良心血管事件发生率均低于对照组,差异有统计学意义(P<0.05)。结论:比索洛尔联合常规治疗可显著改善COPD合并CVD患者的肺功能指标,并减轻呼吸困难,提升生活质量,降低急性加重再住院率及不良心血管事件发生率。

Objective:To explore the effect of Bisoprolol combined with conventional treatment on chronic obstructive pulmonary disease(COPD)complicated with cardiovascular disease(CVD).Method:A total of 80 patients with COPD complicated with CVD admitted to the Zhangzhou Guleigang Economic Development Zone First Hospital from January 2019 to January 2022 were selected.According to the method of random number table,they were divided into control group and study group,40 cases in each group.The control group was given conventional treatment,and the study group was given Bisoprolol Fumarate Tablets on the basis of the control group.Pulmonary function,dyspnea condition,exercise endurance,quality of life before and after treatment,acute aggravation rehospitalization,adverse cardiovascular events and mortality were compared between the two groups.Result:After treatment,blood oxygen saturation,forced expiratory volume in the first second/forced vital capacity(FEV_(1)/FVC%),maximum gas volume per minute,and 6-minute walking test distance in the study group were all higher than those in the control group,and respiratory rate and respiratory BORG fatigue index scores were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the scores of overall health,mental health,emotional function,role physical,physiological function and social function of the two groups were improved compared with those before treatment,and the scores of overall health,mental health,emotional function,role physical,physiological function and social function of the study group were higher than those of the control group,the differences were statistically significant(P<0.05).The re-hospitalization rate of acute aggravation and the incidence of adverse cardiovascular events in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Bisoprolol combined with conventional treatment can significantly improve pulmonary function indicators in COPD patients complicated with CVD,alleviate dyspnea,improve quality of life,and reduce the rate of acute aggravation re-hospitalization and the incidence of adverse cardiovascular events.