介入治疗对急性脑梗死患者血清Hcy及血浆TXB2、6-K-PGF1α水平的影响

Effect of interventional therapy on serum Hcy and plasma TXB2,6-K-PGF1αlevels in patients with acute cerebral infarction

目的探讨急性脑梗死患者介入治疗前后血清同型半胱氨酸(Hcy)及血浆血栓素B2(TXB2)、6-酮前列腺素F1α(6-K-PGF1α)检测的临床价值。方法选取接受介入治疗的45例急性脑梗死患者作为观察组,按1∶1比例选取同期进行健康体检的45例非脑梗死人群作为对照组。比较对照组及观察组患者治疗前后、不同梗死面积患者血清Hcy和血浆TXB2、6-K-PGF1α水平差异。结果治疗前,观察组患者的血清Hcy及血浆TXB2、6-K-PGF1α水平均高于对照组(均P<0.05);观察组大面积梗死、中面积梗死、小面积梗死患者的血清Hcy、血浆TXB2水平依次降低(均P<0.05);但不同梗死面积患者的血浆6-K-PGF1α水平比较,差异无统计学意义(P>0.05)。预后良好组患者血清Hcy和血浆TXB2、6-K-PGF1α水平明显低于治疗前和预后不良组(均P<0.05);而预后不良组患者血清Hcy和血浆TXB2、6-K-PGF1α水平与治疗前比较,差异均无统计学意义(均P>0.05)。观察组患者血清Hcy水平与血浆TXB2、6-K-PGF1α水平呈正相关(r=0.518,P<0.05;r=0.601,P<0.05);血清Hcy及血浆TXB2、6-K-PGF1α水平与脑梗死面积呈正相关(r=0.412,P<0.05;r=0.557,P<0.05;r=0.349,P<0.05)。结论急性脑梗死患者治疗前血清Hcy和血浆TXB2、6-K-PGF1α水平均较非脑梗死人群高,且其水平随病情加重而升高,检测血清Hcy和血浆TXB2、6-K-PGF1α水平对于了解患者病情及预后有重要的临床意义。

Objective To investigate the clinical value of serum homocysteine(Hcy),plasma thromboxane B2(TXB2)and 6-keto prostaglandin F1α(6-K-PGF1α)detection in patients with acute cerebral infarction before and after interventional therapy.Methods A total of 45 patients with acute cerebral infarction who received interventional therapy were selected as the observation group,and 45 people with non-cerebral infarction who underwent physical examination at the same period were selected as the control group according to the ratio of 1∶1.The levels of serum Hcy and plasma TXB2,6-K-PGF1αwere compared between the control group and the observation group before and after treatment,and in patients with different infarct areas.Results Before treatment,the levels of serum Hcy and plasma TXB2,6-K-PGF1αin the observation group were higher than those in the control group(all P<0.05).The levels of serum Hcy and plasma TXB2 in patients with large area infarction,medium area infarction,and small area infarction in the observation group decreased sequentially(all P<0.05).However,there was no statistically significant difference in the level of plasma 6-K-PGF1αin patients with different infarct areas(P>0.05).The levels of serum Hcy and plasma TXB2,6-K-PGF1αin patients with good prognosis were significantly lower than those before treatment and those in patients with poor prognosis(all P<0.05).However,there were no statistically significant differences in the levels of serum Hcy and plasma TXB2,6-K-PGF1αbefore and after treatment in the poor prognosis group(all P>0.05).The level of serum Hcy in the observation group was positively correlated with the levels of plasma TXB2 and 6-K-PGF1α(r=0.518,P<0.05;r=0.601,P<0.05);and the levels of serum Hcy and plasma TXB2,6-K-PGF1αwere positively correlated with cerebral infarction area(r=0.412,P<0.05;r=0.557,P<0.05;r=0.349,P<0.05).Conclusion The levels of serum Hcy and plasma TXB2,6-K-PGF1αin patients with acute cerebral infarction before treatment were higher than those in non-cerebral infarction population,and their levels increased with the aggravation of the disease.The detection of serum Hcy and plasma TXB2,6-K-PGF1αlevels has important clinical significance for understanding the condition and prognosis of patients.