2020—2022年重庆市某二级医院肠杆菌科细菌耐药性分析

Drug resistance analysis of Enterobacteriaceae in a secondary hospital in Chongqing from 2020 to 2022

目的:了解该院肠杆菌科细菌菌株分布及其耐药性,为抗菌药物合理使用提供理论依据。方法:分析2020—2022年临床分离的肠杆菌科细菌实验室数据及其患者的临床资料。结果:共收集肠杆菌科细菌4526株,以大肠埃希菌、肺炎克雷伯菌、阴沟肠杆菌为主。耐碳青霉烯类大肠埃希菌检出率2020—2022年无较大波动,一直维持在较低水平,耐碳青霉烯类的肺炎克雷伯菌和阴沟肠杆菌检出率呈逐年上升的趋势、2022年检出率分别为9.9%和14.5%。结论:耐碳青霉烯类肺炎克雷伯菌和阴沟肠杆菌检出率逐年增加,临床应合理使用抗菌药物,并严格落实院感防控措施,减少耐药菌的产生。

Objective To investigate the distribution and drug resistance of Enterobacteriaceae strains in the hospital,and to provide theoretical basis for the rational use of antibiotics.Methods The laboratory data of clinical isolates of Enterobacteriaceae from 2020 to 2022 and the clinical data of the patients were analyzed.Results A total of 4526 strains of Enterobacteriaceae were collected,mainly Escherichia coli,Klebsiella pneumonia and Enterobacter cloacae.From 2020 to 2022,the detection rate of carbapenemresistant Escherichia coli had no great fluctuation and remained at a low level.The detection rates of carbapenem-resistant Klebsiella pneumoniae and Enterobacter cloacae showed an increasing trend year by year,and the detection rates in 2022 were 9.9%and 14.5%,respectively.Conclusion The detection rates of carbapenem-resistant Klebsiella pneumoniae and Enterobacter cloacae increased year by year.Clinical use of antibiotics should be rational,and strict implementation of disinfection and isolation measures to reduce the production of drug-resistant bacteria.