甘油三酯与高密度脂蛋白胆固醇比值在心房颤动患者中的表达及与心血管事件的关系

Expression of Triglyceride and High Density Liptein Cholesterol Ratio in Patients with Atrial Fibrillation and Its Relationship with Cardiovascular Events

目的观察甘油三酯(TG)与高密度脂蛋白胆固醇(HDL-C)比值在心房颤动患者中的表达,并分析TG/HDL-C与心房颤动患者心血管事件的关系。方法本研究为前瞻性分析,纳入南阳市中心医院2020年5月至2021年8月收治的88例心房颤动患者,所有患者均接受12个月随访。根据心房颤动患者TG/HDL-C的中位数将其分为高比值组和低比值组,比较两组患者随访期间发生的心血管事件(急性冠脉综合征、心力衰竭、恶性心律失常);采用点二列相关性检验TG/HDL-C与心房颤动患者发生心血管事件的关系;采用logistic回归分析影响心房颤动患者发生心血管事件的危险因素。结果共纳入88例心房颤动患者,剔除2例,最终86例患者完成研究,86例心房颤动患者TG/HDL-C为0.65~3.68,中位数为1.41。高比值组(TG/HDL-C值≥1.41)42例患者,低比值组(TG/HDL-C值<1.41)44例患者。随访期间,相较低比值组,高比值组发生急性冠脉综合征、心力衰竭及恶性心律失常的患者更多,心血管事件总发生率更高(P<0.05)。经点二列相关性分析,TG/HDL-C与心房颤动患者发生心血管事件呈正相关(r>0,P<0.05)。经logistic回归检验,结果显示,TG/HDL-C高是影响心房颤动患者发生心血管事件的危险因素(OR>1,P<0.05)。结论心房颤动患者TG/HDL-C高是心血管事件发生的危险因素。

Objective To observe the expression of triglyceride(TG)and high density liptein cholesterol(HDL-C)ratio in patients with atrial fibrillation,and analyze the relationship between TG/HDL-C and cardiovascular events in patients with atrial fibrillation.Methods This study was a prospective analysis,including 88 patients with atrial fibrillation admitted to Nanyang Central Hospital from May 2020 to August 2021.All patients were followed up for 12 months.According to the median TG/HDL-C of patients with atrial fibrillation,they were divided into high ratio group and low ratio group,and the cardiovascular events(acute coronary syndrome,heart failure,malignant arrhythmia)occurred during follow-up were compared between the two groups.The relationship between the TG/HDL-C and the occurrence of cardiovascular events in patients with atrial fibrillation was tested by point binary correlation.Logistic regression analysis was used to examine the risk factors of cardiovascular events in patients with atrial fibrillation.Results A total of 88 patients with atrial fibrillation were included and 2 cases were excluded.Finally,86 patients completed the study.The TG/HDL-C of 86 patients with atrial fibrillation was 0.65-3.68,with a median of 1.41.There were 42 patients in the high ratio group(TG/HDL-C was≥1.41)and 44 patients in the low ratio group(TG/HDL-C was<1.41).During the follow-up period,compared with the low ratio group,the high ratio group had more patients with acute coronary syndrome,heart failure and malignant arrhythmia,and the total incidence of cardiovascular events was higher than that in the low ratio group(P<0.05).Through point binary correlation analysis,TG/HDL-C was positively correlated with the occurrence of cardiovascular events in patients with atrial fibrillation(r>0,P<0.05).Logistic regression test showed that the high TG/HDL-C was a risk factor for cardiovascular events in patients with atrial fibrillation(OR>1,P<0.05).Conclusion The high TG/HDL-C in patients with atrial fibrillation is a risk factor for cardiovascular events.