急性布鲁氏菌病患者血清蛋白电泳测定结果分析

Analysis of serum protein electrophoresis results in patients with acute brucellosis

目的了解急性布鲁氏菌病(布病)患者血清蛋白电泳测定结果,为急性布病患者临床诊断及治疗提供客观指标。方法以2021年1-6月包头市东河区疾病预防控制中心确诊的30名急性布病患者作为病例组,选择同期参加体检的30名当地健康者作为对照组。采集两组人群血液,分离血清,进行血清蛋白电泳测定。采用独立样本t检验,比较两组人群血清蛋白电泳图谱中总蛋白含量,白蛋白、α1-球蛋白、α2-球蛋白、β-球蛋白、γ-球蛋白所占总蛋白百分比和白蛋白/球蛋白(A/G)比值。结果病例组患者年龄为(52.35±6.74)岁,其中男性25人、女性5人,病程为0.3~2.6个月,平均1.78个月;对照组人群年龄为(52.74±5.47)岁,其中男性25人、女性5人。两组年龄和性别分布比较差异均无统计学意义(均P>0.05)。病例组血清总蛋白含量、α2-球蛋白所占总蛋白百分比与对照组比较,差异均无统计学意义(t=0.78、2.04,均P>0.05);血清白蛋白、α1-球蛋白、β-球蛋白、γ-球蛋白所占总蛋白百分比,A/G比值与对照组比较,差异均有统计学意义(t=4.78、4.76、2.89、2.20、3.65,均P<0.05)。结论急性布病患者血清白蛋白所占总蛋白百分比、A/G比值降低,α1-球蛋白、β-球蛋白、γ-球蛋白所占总蛋白百分比升高。血清白蛋白、α1-球蛋白、β-球蛋白、γ-球蛋白所占总蛋白百分比,A/G比值可作为急性布病患者临床诊断及治疗客观指标。

Objective To understand the results of serum protein electrophoresis in patients with acute brucellosis,and to provide objective indicators for clinical diagnosis and treatment of acute brucellosis patients.Methods Thirty acute brucellosis patients diagnosed by the Center for Disease Prevention and Control of Donghe District,Baotou City from January to June 2021 were selected as the case group,and 30 local healthy persons who took physical examination during the same period were selected as the control group.Blood samples were collected from the two groups of people,serum was separated and serum protein electrophoresis was performed.Independent sample t-tests were used to compare total protein concentrations,protein fractions(albumin,α1-globulin,α2-globulin,β-globulin andγ-globulin)and albumin/globulin(A/G)ratio.Results The age of patients in the case group was(52.35±6.74)years old,with 25 males and 5 females.The course of the disease ranged from 0.3 to 2.6 months,with an average of 1.78 months.The age of people in the control group was(52.74±5.47)years old,with 25 males and 5 females.There were no statistically significant difference in age and sex distuibution between the two groups(P>0.05).The concentrations of total protein andα2-globulin fractions were not significantly different between the two groups(t=0.78,2.04,P>0.05,respectively).Compared with the control group,the differences in the percentage of albumin,α1-globulin,β-globulin,γ-globulin in total protein and A/G ratio were statistically significant(t=4.78,4.76,2.89,2.20,3.65,P<0.05).Conclusions The percentage of serum albumin in total protein and A/G ratio decrease in patients with acute brucellosis,while the percentage ofα1-globulin,β-globulin andγ-globulin in total protein increase.The percentage of albumin,α1-globulin,β-globulin,γ-globulin in total protein and A/G ratio can be uesed as objective indicators for clinical treatment of acute brucellosis.