嗜黏蛋白阿克曼氏菌治疗疾病的潜力与作用机制研究进展

Potential and mechanism of Akkermansia muciniphila in disease treatment

嗜黏蛋白阿克曼氏菌(Akkermansia muciniphila,AKK)可促进肠道黏液分泌,维持肠道黏液动态平衡,调节肠黏膜屏障功能,在机体代谢调节、免疫应答中发挥重要作用。AKK对肠道炎症、神经炎症、机体代谢紊乱和癌症等疾病具有显著改善作用,被视为极具潜力的下一代益生菌。本文分别从消化系统、神经系统、代谢性紊乱和癌症等角度入手,系统概述AKK在疾病治疗中的潜力及作用分子机制。

Akkermansia muciniphila(AKK)promotes the secretion,maintains the dynamic balance,and regulates the barrier function of intestinal mucus,playing a key role in metabolic regulation and immune response.As a promising next-generation probiotic,AKK can mitigate diseases such as intestinal inflammation,metabolic disorders,neuroinflammation,and cancers.We introduced the therapeutic potential of AKK for diseases of the digestive system,the nervous system,metabolic disorders and cancers,aiming to provide a systematic review of the potential role and molecular mechanism of AKK in disease treatment.