基于益生菌治疗帕金森病的研究进展

Progress in probiotics for Parkinson’s disease

帕金森病是常见的神经退行性疾病,其发病原因至今尚未明确,目前的治疗方法价格昂贵、效果差且副作用大。帕金森病患者常见胃肠道功能障碍,帕金森病和肠道菌群之间的关联已得到实验证实,患者有望通过益生菌改善肠道菌群达到治疗的目的。工程益生菌的出现使得人们可以按照自己的意愿改造益生菌,提高其稳定性和靶向性,展现出其特有的应用潜力。本文将从益生菌治疗帕金森病的研究现状出发,阐述益生菌治疗帕金森病的可能机制,进一步分析工程益生菌治疗帕金森病的可行性,为该疾病的安全治疗提供新的思路。

Parkinson's disease is a common neurodegenerative disease with the cause remaining unknown.The available therapies are characterized by high costs,limited efficacy,and strong side effects.Gastrointestinal dysfunction is common in the patients with Parkinson's disease.Studies have demonstrated the association between Parkinson's disease and intestinal flora,and the patients are expected to be treated by probiotics which can restore the intestinal flora.The engineering of probiotics makes it feasible to modify probiotics according to people’s wishes and improve their stability and targeting,thus giving full play to the role of probiotics in disease treatment.We reviewed the relevant studies in recent years,elaborated on the possible treatment mechanisms,and further analyzed the feasibility of engineering probiotics in the treatment of Parkinson’s disease,aiming provide new ideas for the safe treatment of this disease.