乳杆菌胞外多糖合成基因簇及构效关系

Lactobacillus exopolysaccharide:gene clusters for synthesis and structure-activity relationship

肠道菌群稳态对维护人体的健康具有至关重要的作用。作为肠道天然微生物群“守卫兵”,益生菌参与改善体内微生态平衡。乳杆菌(Lactobacillus)是一种肠道益生菌的代表,其合成的胞外多糖(exopolysaccharide,EPS)既可通过增益肠道内其他益生菌的生长来优化肠道微生态,还具有抗肿瘤、抗氧化、降胆固醇、降血压和增强机体免疫力等益生功能。本文对近年来乳杆菌胞外多糖的遗传、生物学活性、构效关系等方面的研究进展,进行综述和展望。

Intestinal microflora homeostasis plays a crucial role in maintaining human health.As a guard of the natural intestinal microflora,probiotics improve the microecological balance in the host.Lactobacillus is a representative of intestinal probiotics.The exopolysaccharide(EPS)synthesized by Lactobacillus can optimize the intestinal microecology by promoting the growth of other probiotics in the intestine.Moreover,EPS is praised for anti-tumor,antioxidant,cholesterol-lowering,blood pressure-lowering,and immunity-enhancing activities.This article reviews the research progress in the genetics,biological activities,structure-activity relationship of Lactobacillus EPS in recent years.