质谱技术在北美临床检验中的应用

Application of mass spectrometry in clinical laboratory in North America

早期滥用药物的检测推动了质谱技术在北美临床实验室的应用。质谱分析因为其分析灵敏度、特异性和同时检测的能力优势,已经越来越广泛的应用于临床。目前,质谱技术已经成功用于临床小分子化合物、多肽、蛋白质、临床毒理和微生物等常规检测。尽管还需要更多经过FDA批准的商品化平台和试剂,但毫无疑问质谱技术已经展现出丰富的临床应用。

Detection of early drug abuse has driven the use of mass spectrometry in clinical laboratories across North America.Mass spectrometry-based assays have been increasingly implemented in various clinical disciplines for their advantages in high analytical sensitivity,specificity and multiplexing capacity.Mass spectrometry is now routinely used for the clinical analysis of small molecule compounds,peptides,proteins,clinical toxicology and microbiology.Although more FDA-approved platforms and reagents need to be commercially available,there is no doubt that mass spectrometry technology has demonstrated rich clinical applications.