亚铁离子和亚铁血红素的小分子荧光探针研究进展

Research progress of small molecule fluorescent probes for ferrous ion and heme

小分子荧光探针以其选择性好、灵敏度高、便于操作等优点受到了广泛的关注,在许多物种的检测中发挥了重要的作用,并且在生物医药领域的研究中也表现出了巨大的潜力。铁作为人体中含量最丰富的过渡金属,利用其氧化还原能力在许多生理功能中都扮演着关键的角色。由于细胞还原性微环境的影响,亚铁离子(Fe2+)是活细胞中游离铁的主要组成部分。亚铁血红素(heme)由Fe2+和原卟啉IX组成,是将人体内生物铁包裹在其中的主要信号分子之一,同样参与许多生理病理过程。因此,开发用于检测Fe2+及heme的小分子荧光探针作为有效监测工具将有助于进一步了解它们的病理及生理功能,并有望应用于其他领域。本文综述了近年来用于检测Fe2+和heme的小分子荧光探针研究进展,并对未来的发展方向进行了展望。

Small molecule fluorescent probes have gained widespread attention for their advantages of high selectivity,sensitivity,and easy to operate,and have played a critical role in the detection of various species.They have also demonstrated great potential in the field of biomedical research.Iron,as the most abundant transition metal in the human body,plays a vital role in many physiological functions.Due to the influence of the reductive microenvironment of cell,ferrous ion(Fe2+)is the main component of labile iron in living cells.Heme,consisting of Fe2+and protoporphyrin IX,is one of the main signaling molecules that wrap biological iron in the human body,and also participates in many physiological and pathological processes.Therefore,the development of small molecule fluorescent probes for detecting Fe2+and heme as effective monitoring tools will help to further understand their pathological and physiological functions,with potential applications in other fields.This review summarizes the research progress of small molecule fluorescent probes for Fe2+and heme detection in recent years,and provides insights into future directions for their development.