代谢组学技术在生物医药领域研究中的创新与应用

Innovation and application of metabolomics technology for research in the biomedical field

代谢组学技术在生物医药领域研究中发挥着重要作用,如疾病诊断、发病机制解析、药物靶点探索、治疗指南制定等,由于代谢组学研究有系统性、整体性等特点,所以在剖析中药药效物质基础和开发中药新药方面表现出了一定优势。随着代谢组学研究的持续创新,目前已经开发出许多先进的新技术,弥补了常规代谢组学研究在寻找疾病靶点、识别功能化合物、阐释生物学意义等方面的不足。此外,代谢组学技术的快速发展,为疾病诊断和中药新药开发创造了新的机遇。在此基础上,有别于常规代谢组学技术和方法,本文从新工具、新思路和新样本角度综述了近10年具有广泛应用前景的9种代谢组学新技术,以期为生物医药领域相关代谢组学研究提供新视角,为代谢组学技术的创新和发展提供新动力。

Metabolomics technology played an important role in the field of biomedical research,such as disease diagnosis,pathogenesis analysis,drug target exploration,formulation of treatment guidelines,etc.Due to the systematic and holistic characteristics of metabolomics research,it has shown certain advantages in the analysis of the basis of pharmacodynamic substances of traditional Chinese medicines and the development of new medicines from traditional Chinese medicines.With the continuous innovation of metabolomics research,many advanced technologies have been developed,which make up for the shortcomings of conventional metabolomics studies in searching for disease targets,identifying functional compounds and interpreting biological significance.Furthermore,the rapid development of metabolomics technology has created new opportunities for the diagnosis of diseases and the development of new drugs in traditional Chinese medicine.Herein,different from conventional metabolomics techniques and methods,nine new metabolomics technologies with wide application prospects in the past 10 years were reviewed from the perspective of new tools,new ideas and new samples,with a view to providing new insights on relevant metabolomics research in the biomedical field and providing new motivation for innovation and development of metabolomics technologies.