经皮给药技术用于脑靶向药物递送

Transdermal drug delivery technology for brain-targeted drug delivery

中枢神经系统疾病治疗药物的脑内递送通常受到血脑屏障(blood brainbarrier,BBB)的限制。经皮给药系统(transdermal drugdelivery systems,TDDS)相较于静脉注射、口服给药和经鼻给药,具有提高患者对药物的依从性以及避免了首过效应的优势,是一种新兴的非侵入型药物的递送方式,有利于患者长期给药。淋巴通路直接从皮下靶向脑组织的途径的发现使得TDDS成为一种新型脑靶向药物递送策略。同时,纳米递药技术发展进一步促进了TDDS在脑部靶向药物递送的应用。本文综述了经皮给药入脑机制并总结了TDDS在脑部疾病治疗中的应用,为中枢神经系统疾病治疗提供了新的思路和方法。

Intracerebral delivery of drugs for the treatment of central nervous system disorders is usually limited by the blood-brain barrier(BBB).Transdermal drug delivery systems(TDDS)have the advantage of improving patient compliance and avoiding first-pass effects compared to intravenous,oral and intranasal drug delivery,and are an emerging non-invasive drug delivery route that facilitates long-term drug delivery to patients.The discovery of direct subcutaneous targeting of lymphatic pathways to brain tissue has made TDDS a new braintargeted drug delivery strategy.At the same time,the development of nano-delivery technology has further facilitated the application of TDDS for targeted drug delivery to the brain.This review summarizes the mechanism of transdermal drug delivery into the brain and the application of TDDS in the treatment of brain diseases,providing new ideas and methods for the treatment of central nervous system diseases.