粪肠球菌逃逸宿主免疫防御机制的研究进展

Research progress on mechanism of Enterococcus faecalis escaping host immune defense

粪肠球菌是持续性根尖周炎中最主要的致病菌,含有多种毒力因子。宿主免疫防御能调动体内多种免疫细胞以及免疫分子来调控机体的炎症反应,可在粪肠球菌引起的持续性根尖周炎中发挥重要作用。然而,粪肠球菌在入侵机体的过程中可因多种逃逸及抵抗宿主免疫防御的机制,使其在宿主体内存活,进而造成组织损伤。本文对近年来粪肠球菌逃逸宿主免疫防御机制的研究进展作一综述,旨在从免疫角度探究粪肠球菌在根尖周组织中不易被清除机制,以期为持续性根尖周炎的防治提供新的思路。

Enterococcus faecalis is the main pathogenic bacteria in persistent apical periodontitis,which contains a variety of virulence factors.The host immune defense can mobilize a variety of immune cells and immune molecules in the body to regulate the body’s inflammatory response,which can play an important role in persistent periapical periodontitis caused by Enterococcus faecalisis.However,in the process of invading the body,Enterococcus faecalisis can form a variety of mechanisms to escape host defense immunity,so that it can survive in the host and cause damage.This article will review the research progress on the immune defense mechanism of Enterococcus faecalisis escaping the host,aiming to explore why Enterococcus faecalisis cannot be cleared in the periapical tissue from the perspective of immunity,in order to provide new information for the prevention and treatment of persistent periapical periodontitis idea.