孕激素在子宫颈机能不全中的应用

Application of progesterone in cervical insufficiency

孕激素是一种类固醇激素,在月经周期的维持、胚胎着床和妊娠的每个阶段都必不可少。自孕激素类药物合成以来,孕激素治疗已被用于预防和治疗着床失败、流产和早产,其中在子宫颈机能不全的作用也被认可。随着循证医学的发展,虽然关于孕激素实际作用的证据已经大大增加,但仍然存在许多争议。文章阐述了孕激素在子宫颈机能不全中应用的相关内容。

Progesterone is a steroid hormone which plays an essential role in the menstrual cycle and implantation and at each step of human pregnancy.Since the synthesis of progesterone drugs,progesterone therapy has been used to prevent and treat implantation failure,miscarriage and premature birth,and is also used in cervical insufficiency.With the development of evidence-based medicine,although the evidence about the actual roles of progesterone have increased greatly,many controversies still remain.The purpose of this review is to summarize knowledge about the use of progesterone in cervical insufficiency.