具有抗炎作用的药物在抑郁症治疗中的研究进展

Research progress of anti-inflammatory agents in the treatment of major depressive disorder

抑郁症是常见的精神疾病之一,其发病机制尚未完全明确,机体炎症水平升高是目前公认的抑郁症发病机制之一。大量研究表明,非甾体类抗炎药、ω-3脂肪酸、他汀类药物、吡格列酮、米诺环素、N-乙酰半胱氨酸、皮质类固醇等药物可能通过抗炎作用发挥抗抑郁疗效。本文就上述药物在抗抑郁治疗中的应用进行综述,探讨具有抗炎作用的药物对抑郁症治疗的效果及其可能的作用机制,为未来抗炎干预在抑郁症治疗中的应用提供参考。

Major depressive disorder is one of the common mental disorders,and its pathogenesis is not yet fully understood.Elevated levels of inflammation are recognized as one of the mechanisms contributing to the onset of major depressive disorder.Numerous studies have indicated that non-steroidal anti-inflammatory drugs,omega-3 fatty acids,statins,pioglitazone,minocycline,N-acetylcysteine,corticosteroids and other medications may exert anti-depressant effects through their anti-inflammatory actions.This article provides a comprehensive review of the application of these drugs in the treatment of major depressive disorder,exploring the therapeutic effects and potential mechanisms of action of different anti-inflammatory agents,thereby offering a reference for the future application of anti-inflammatory interventions in the treatment of depression.