血清维生素D水平与卵巢血流动力学及卵巢储备功能相关性研究

Study on the relationship between vitamin D level and ovarian blood flow and ovarian reserve function

目的分析血清维生素D水平与卵巢血流动力学及卵巢储备功能的相关性。方法回顾性队列研究选取2020年9月至2021年11月期间哈尔滨医科大学附属第二医院妇产科收治的年龄18~40岁、性生活规律的女性为研究对象。收集患者年龄、身高、体质量等资料,检测患者补充维生素D前后血清维生素D、抗苗勒管激素(anti-Müllerian hormone,AMH)、黄体生成素、卵泡刺激素等指标,采用彩色多普勒超声仪器测量窦卵泡计数及早卵泡期双侧卵巢间质动脉血流阻力指数(resistance index,RI)、搏动指数(plusatility index,PI)。多重线性回归分析血清维生素D水平相关影响因素。结果研究共纳入女性218例,其中维生素D缺乏137例,占62.8%;维生素D不足39例,占17.9%;维生素D正常42例,占19.3%。多重线性回归分析显示,血清维生素D水平与卵巢间质动脉血流RI之间存在负相关(P=0.025);与其余指标之间均无相关性(均P>0.05)。结论血清维生素D水平在一定程度上影响了女性卵巢间质动脉血流RI,但与卵巢间质动脉血流PI、血清AMH水平及其他卵巢储备功能相关指标并无明显关联。

Objective To analyze the correlation between serum vitamin D level and ovarian artery blood flow index and ovarian reserve function in women.Methods A retrospective cohort study was conducted.Women aged from 18 to 40 years who were admitted to the Department of Obstetrics and Gynecology of the Second Affiliated Hospital of Harbin Medical University from September 2020 to November 2021 and had regular sexual life were selected as subjects.The data of age,height and weight were collected.And the indexes of vitamin D,anti-Müllerian hormone(AMH),luteinizing hormone and follicle-stimulating hormone were detected in the laboratory.Color Doppler ultrasound was used to measure antral follicle count and bilateral ovarian interstitial artery blood stream resistance index(RI)and plusatility index(PI)in early follicular phase.Multiple linear regression was used to analyze the related factors of serum vitamin D level.Results A total of 218 women were included in the study,including 137 cases of vitamin D deficiency,accounting for 62.8%,39 cases of vitamin D insufficiency,accounting for 17.9%,42 cases of normal vitamin D,accounting for 19.3%.Multiple linear regression analysis showed that there was a negative correlation between serum vitamin D level and ovarian blood flow(P=0.024),but no correlation with other indexes(all P>0.05).Conclusion Serum vitamin D level affected ovarian interstitial artery blood flow RI to some extent,but had no significant correlation with ovarian interstitial artery blood flow PI,serum AMH level and other indexes related to ovarian reserve function.