多囊卵巢综合征临床、代谢表型及远期并发症与抑郁、焦虑关系的研究进展

Progress on depression and anxiety in polycystic ovary syndrome:impact of clinical and metabolic phenotypes and long-term complications

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄期妇女常见的生殖内分泌疾病。PCOS患者易发心理障碍,其中尤以抑郁、焦虑的发病率最高。PCOS与抑郁、焦虑的相关性是近年研究的热点问题,研究表明PCOS临床、代谢表型及远期并发症所致的生化改变和心理压力可能解释了抑郁、焦虑产生的机制。本文对PCOS表型及远期并发症与抑郁、焦虑发生的相关研究展开综述,总结现有的研究结果,以期厘清PCOS对抑郁、焦虑的潜在影响因素,为后续研究和临床工作提供帮助。

Polycystic ovary syndrome(PCOS)is a common reproductive endocrine disorder in women of childbearing age.Patients with PCOS are more likely to have psychological disorders such as anxiety and depression.In recent years,researchers have explored the link between PCOS and depression and anxiety.The biochemical changes and psychological stress experienced by PCOS patients caused by different clinical and metabolic phenotypes and long-term complications may account for the high levels of depression and anxiety experienced by women with PCOS risk.The purpose of this review was to summarize the present findings on PCOS phenotype and long-term complications related to depression and anxiety,to clarify the factors that may contribute to depression and anxiety,and to formulate future study directions and clinical practice.