舒肝宁注射液利胆退黄抗炎护肝机制研究进展

Mechanism of Shuganning’s roles in promoting gallbladder motion,relieving jaundice,anti-inflammatory and protecting liver functions

随着中西医结合治疗肝病研究的深入开展,肝病治疗的新方法、新药物不断涌现,中医药单靶点叠加作用、多靶点协同作用和毒性分散效应可为肝病治疗提供更多的思路,成为丰富完善肝病治疗方法的重要路径。舒肝宁注射液是基于经典名方茵陈蒿汤的现代中药制剂。本文从肝脏转运体、代谢酶和核受体等不同角度对舒肝宁的利胆退黄机制进行了分析,从肝巨噬细胞和氧化应激反应两个方面对其抗炎护肝机制进行阐述,以期为舒肝宁注射液现代中药组方的临床用药提供依据。

With the in-depth development of liver disease research with integrated traditional Chinese and Western medicine,new approaches and new medicines for liver disease treatment continue to emerge.The traditional Chinese medicine single-target superposition,multi-target synergistic effects and toxic dispersion effects provide more ideas for liver disease treatment and become a rich source of an important way to improve the treatment of liver disease.In this paper,we introduce the mechanism of Shuganning,a herbal medicine compound,in relieving bile and reducing jaundice from the perspectives as follows:liver transporters,metabolic enzymes and nuclear receptors,and its anti-inflammatory and hepatoprotective mechanism.