摘要
糖尿病是全世界患病人数较多的慢性疾病之一,严重的糖尿病并发症一直是困扰临床的难题。糖尿病及其并发症的发生机制复杂,且很多机制尚未阐明。近年来,研究发现糖尿病和衰老在发生机制上存在许多交联之处。本文通过文献回顾,总结分析二者的相互作用机制,并加以综述,旨在对今后相关临床与基础研究提供指导。
Diabetes mellitus(DM)is one of the most common chronic diseases in the world.Serious complications of DM have been a difficult problem in clinical practice.The pathogenesis of DM and its complications is complex,and many of the mechanisms have not yet been clarified.In recent years,it has been found that there are many cross-links between the pathogenesis of DM and aging.In this paper,the interaction mechanism of the two is summarized and analyzed by literature review,aiming to provide guidance for future clinical and preclinical research.
作者
陈榕
成艳美
郑小飞
王华军
CHEN Rong;CHENG Yanmei;ZHENG Xiaofei;WANG Huajun(Department of Sports Medicine,the First Affiliated Hospital of Jin'an University,Guangzhou 510630,China;ICU of Cardiothoracic Surgery,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China)
出处
《转化医学杂志》
2023年第4期204-209,214,共7页
Translational Medicine Journal
基金
国家自然科学基金项目(82074511,81973660)
广州市基础与应用基础项目(202102010079)
中央高校基本科研业务费专项资金资助项目(21620452)
暨南大学附属第一医院临床前沿新技术项目(JNU1AF-CFTP-2022-a01204)。
关键词
糖尿病
衰老
高血糖
胰岛素样生长因子
脂肪毒性
衰老相关分泌表型
相关性
综述
Diabetes mellitus
Aging
Hyperglycemia
Insulin-like growth factor
Lipotoxicity
Aging-related secretion phenotype
Correlation
Review
