金属纳米颗粒-刺激响应型水凝胶:活性成分递送体系研究进展

Metal nanoparticle-stimulus-responsive hydrogel composites:Research of active components delivery system

刺激响应型水凝胶活性成分递送体系因其对不同环境具有独特的溶胀和降解特性,在食品、医药等领域已有广泛研究。然而,部分水凝胶作为活性成分递送载体时存在荷载效率和靶向释放效率低等问题。基于金属纳米颗粒具有高比表面积和多孔结构的特点,可增强刺激响应型水凝胶的活性成分荷载能力。将金属纳米颗粒和刺激响应型水凝胶杂化制备得到的复合材料,在环境响应型的活性成分递送和控制释放领域已得到大量研究。论文综述了金属纳米颗粒-刺激响应型水凝胶复合材料的特点、种类和制备方法,总结了其在活性成分递送领域的应用,并对其作为递送体系的未来发展进行了展望。

The stimulus-responsive hydrogel active components delivery system has been widely used in food,medicine,and other fields because of its unique swelling and degradation characteristics in different environments.However,some hydrogels have some problems such as low active components loading rate and low targeting release efficiency when they are used as active components delivery carriers.Based on the characteristics of high surface area and porous structure,metal nanoparticles can enhance the active component loading capacity of stimulus-responsive hydrogels.The composites prepared by the hybrid of metal nanoparticles and stimulus-responsive hydrogels have been widely studied in the field of environmentally responsive active components delivery and controlled release.This paper mainly reviewed the characteristics,types,and preparation methods of metal nanoparticles-stimulus-responsive hydrogel composites,summarized their applications in the field of active components delivery,and prospected their future development as the delivery system.