虎符铜砭刮痧治疗尿毒症皮肤瘙痒的效果及其对C反应蛋白和白细胞介素-6水平的影响

Effect of Hufu copper board scraping therapy on uremic skin pruritus and its effect on C-reactive protein and interleukin-6 levels

目的:探讨虎符铜砭刮痧治疗尿毒症皮肤瘙痒的疗效及其对C反应蛋白(C-reactive protein,CRP)和白细胞介素-6(interleukin-6,IL-6)水平的影响。方法:选取2022年1月至2022年9月海南省中医院收治的100例尿毒症皮肤瘙痒患者为研究对象,按随机数字表法随机分为对照组与观察组,每组各50例。对照组予以常规基础治疗,观察组在对照组基础上增加虎符铜砭刮痧治疗。评估2组临床疗效,并比较治疗前后改良Dou氏瘙痒量表评分、生活质量评估量表(Short Form 36 Questionnaire,SF-36)评分、尿素下降率(urea reduction rate,URR)、单室尿素清除指数(single-compartment urea clearance index,spKt/V)及血清CRP、IL-6、磷(phosphorus,P)、钙(calcium,Ca)、血肌酐(serum creatinine,SCr)、甲状旁腺激素(parathyroid hormone,PTH)水平。结果:观察组临床总有效率明显高于对照组(分别为92.00%和70.00%,P<0.05)。与对照组相比,观察组改良Dou氏瘙痒量表评分较低,SF-36评分较高(均P<0.05)。治疗后,观察组血清CRP、IL-6、P、PTH水平均明显低于对照组(均P<0.05)。治疗后,2组血清Ca、SCr水平、URR及spKt/V比较差异均无统计学意义(均P>0.05)。结论:虎符铜砭刮痧治疗尿毒症皮肤瘙痒具有良好的疗效和安全性,可有效缓解患者瘙痒症状,改善其生活质量,并降低血清P、PTH及炎症因子CRP、IL-6水平,这可能是其疗效的作用机制。

Objective:To explore the curative effect of Hufu copper board scraping in the treatment of uremic skin pruritus and its effect on the levels of C-reactive protein(CRP)and interleukin-6(IL-6).Methods:A total of 100 patients with uremic skin pruritus who were admitted to Hainan Provincial Hospital of Traditional Chinese Medicine from January 2022 to September 2022 were selected and randomly divided into a control group and an observation group according to the random number table method,with 50 cases in each group.The control group was given routine basic treatment,and the observation group was added with Hufu copper board scraping therapy on the basis of the control group.The clinical efficacy was evaluated between the 2 groups,and the scores of the modified Dou itch scale,Short Form 36 Questionnaire(SF-36),urea reduction rate(URR),single-compartment urea clearance index(spKt/V),and the levels of serum CRP,IL-6,phosphorus(P),calcium(Ca),serum creatinine(SCr),and parathyroid hormone(PTH)between the 2 groups before and after the treatment were compared.Results:The total effective rate of the observation group was significantly higher than that of the control group(92.00%vs 70.00%,P<0.05).Compared with the control group,the modified Dou’s pruritus scale scores in the observation group were lower after the treatment,and the SF-36 score was higher(both P<0.05).After the treatment,the levels of serum CRP,IL-6,P,and PTH in the observation group were significantly lower than those in the control group(all P<0.05).After the treatment,there was no significant difference in serum Ca,SCr levels,URR,and spKt/V between the 2 groups(all P>0.05).Conclusion:Hufu copper board scraping has good efficacy and safety in the treatment of uremic skin pruritus.It can effectively relieve the itching symptoms of patients,improve their quality of life,and reduce serum P,PTH,and inflammatory factors CRP,and IL-6 levels,which may be the mechanism of its efficacy.