TMEM237高表达导致急性髓系白血病患者预后不良

High expression of TMEM237 leads to poor prognosis in patients with acute myeloid leukemia

目的跨膜蛋白237(transmembrane protein 237,TMEM237)在肿瘤中的研究近年来逐渐增多,但是到目前为止其在急性髓系白血病(acute myeloid leukemia,AML)中所扮演的角色仍然是未知的,因此该研究试图去揭示TMEM237作为一种新的致癌基因在AML中的作用。方法本研究基于从TARGET数据库获取的130例AML样本信息,采用Kaplan-Meier曲线和单多因素分析来探究TMEM237表达水平与患者生存时间之间的关系。进一步,使用功能富集分析来解释TMEM237的生物学作用。最后,使用Pearson相关分析获得TMEM237共表达基因,并利用这些基因在CMap数据库获取对AML具有潜在治疗效应的药物。结果生存分析结果表明TMEM237表达水平增高与患者生存时间缩短相关联,单多因素分析发现TMEM237可以作为一种独立的危险因素影响AML患者的预后。其次,富集分析结果显示TMEM237与组蛋白修饰、ATP酶激活等生物学过程有着密切的关系。再次,Pearson相关分析揭示了与TMEM237具有共表达关系的10个基因。最后,发现对AML具有潜在治疗效应的药物如喜树碱、Alsterpaullone等。结论本研究首次揭示TMEM237作为一种新的致癌基因在AML恶性进展中的生物学作用,为AML的诊断和治疗提供了一个潜在的生物标记物。

Objective The researches of Transmembrane protein 237(TMEM237)in tumors have gradually increased in recent years,but until now,there has been no research on TMEM237 in acute myeloid leukemia(AML).Therefore,this study attempts to reveal the function of TMEM237 in AML as a novel oncogene.Methods In this study,based on the information of 130 AML samples obtained from the TARGET database,Kaplan-Meier curve and single multivariate analysis were used to explore the relationship between TMEM237 expression level and patient survival time.Furthermore,functional enrichment analysis was used to explain the biological effects of TMEM237.Finally,Pearson correlation analysis was used to obtain TMEM237 co-expressed genes,and these genes were used to obtain drugs with potential therapeutic effects on AML in the CMap database.Results The results of survival analysis showed that increased expression of TMEM237 was associated with shorter survival time.Single multivariate analysis found that TMEM237 could be used as an independent risk factor to influence the prognosis of AML patients.Secondly,the enrichment analysis results showed that TMEM237 was closely related to biological processes such as histone modification and ATPase activation.Thirdly,Pearson correlation analysis revealed 10 genes that have a co-expression relationship with TMEM237.Finally,drugs with potential therapeutic effects on AML such as camptothecin and Alsterpaullone were discovered.Conclusion This study revealed for the first time the biological role of TMEM237 as a novel oncogene in the malignant progression of AML,and provided a potential biomarker for the diagnosis and treatment of AML.