醒脑静注射液联合纳洛酮对急性脑出血患者认知障碍及炎症因子的影响

Effects of Xingnaojing Injection combined with Naloxone on Cognitive Impairment and Inflammatory Factors in Patients with Acute Intracerebral Hemorrhage

目的 探讨急性脑出血患者联合应用醒脑静注射液与纳洛酮对患者认知障碍及炎症因子的影响。方法 选取2019年1月至2021年10月开平市中心医院收治的82例急性脑出血患者作为研究对象,随机分为对照组与联合组,各41例。对照组给予盐酸纳洛酮,联合组在对照组用药基础上加用醒脑静注射液,比较两组威斯康星卡片分类测试(WCST)评分、白细胞介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、临床疗效。结果 治疗7 d后,两组WCST评估系统的分类、概念形成、学习记忆和认知转移评分升高,且联合组高于对照组,差异有统计学意义(P<0.05);治疗7 d后,两组IL-6、CRP、TNF-α降低,且联合组低于对照组,差异有统计学意义(P<0.05);联合组治疗有效率(95.12%)高于对照组(75.61%),差异有统计学意义(P<0.05)。结论 急性脑出血患者联合应用醒脑静注射液与纳洛酮治疗,疗效理想,可减轻患者认知障碍程度,降低炎症因子水平。

Objective To explore the effects of Xingnaojing injection combined with naloxone on cognitive impairment and inflammatory factors in patients with acute intracerebral hemorrhage.Methods Eighty two patients with acute cerebral hemorrhage admitted to Kaiping Central Hospital from January 2019 to October 2021 were selected as the study subjects and randomly divided into the control group and the combined group,with 41 patients in each group.The control group was given Naloxone hydrochloride,and the combined group was given Xingnaojing injection on the basis of the control group.The Wisconsin Card Sorting Test(WCST) score,Interleukin 6(IL-6),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α) and clinical efficacy were compared between the two groups.Results After 7 days of treatment,the classification,concept formation,learning and memory,and cognitive transfer scores of the WCST evaluation system in the two groups increased,and the combined group was higher than the control group,with a statistically significant difference(P<0.05);After 7 days of treatment,two groups of IL-6,CRP,TNF-α decreased,and the combination group was lower than the control group,with a statistically significant difference(P<0.05);The effective rate of the combination group(95.12%) was higher than that of the control group(75.61%),and the difference was statistically significant(P<0.05).Conclusion The combination of Xingnaojing injection and naloxone in the treatment of patients with acute intracerebral hemorrhage has ideal curative effect,which can reduce the degree of cognitive impairment and the level of inflammatory factors.