助孕者使用重组人促卵泡激素注射液预充式注射笔自行注射能力的量化评估

Quantitative Evaluation of Self-Injection Capacity of Infertile Patient Using Recombinant Human Follicle Stimulating Hormone Injection Prefilled Pen

目的通过比较经验评估法和量化评估法在临床上的应用效果,探索评估助孕者是否具备使用重组人促卵泡激素注射液预充式注射笔自行注射能力的可靠方法,提高助孕者自行注射预充式注射笔的安全性。方法参考文献,建立助孕者重组人促卵泡激素注射液预充式注射笔自行注射能力量化评估法,包含注射相关知识和注射操作两个量化评估表,均设置单项否定因素。在百色某三级甲等医院生殖医学中心,选取2020年1月—2023年3月体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)第一周期经护士同质化注射宣教指导,且促排卵第1天采用两种不同方法1次评估具重组人促卵泡激素注射液预充式注射笔自行注射能力的助孕者212例作为观察对象,采用经验评估法的104例设为对照组,采用量化评估法的108例设为观察组。比较两组本周期内下次复诊日的注射相关知识得分、注射操作得分及人绒毛膜促性腺激素(human chorionic gonadotropin,HCG)注射日注射并发症发生情况。结果注射相关知识得分、注射操作得分、注射相关知识和注射操作20个项目中13个单项得分,观察组均明显高于对照组(P<0.001);观察组注射并发症低于对照组(P<0.05)。结论相比经验评估法,量化评估法更全面客观,能激励助孕者正性学习态度,其掌握注射相关知识和注射操作动作更正确规范,提高助孕者自行注射安全性;利用单项否定因素初步分流,对判断助孕者是否具备使用预充式注射笔自行注射能力具有临床实用价值。

Objective By comparing the clinical application effect of empirical evaluation method and quantitative evaluation method,to explore a reliable method to evaluate whether a infertile patient has self-injection capacity using recombinant human follicle stimulating hormone injection prefilled pen,and to improve the safety of self-injection of infertile patient using prefilled injection pen.Methods According to literature,a quantitative evaluation method of self-injection capacity of recombinant human follicle stimulating hormone injection prefilled pen for infertile patient was established,including two quantitative evaluation tables of knowledge related to injection and injection operation,and single negative factors were set in both of them.In reproductive medicine center of a third class A hospital in Baise,212 infertile patients who had accepted the homogenized injection education and guidance from nurse,just evaluated having self-injection capacity using recombinant human follicle stimulating hormone injection prefilled pen by two different methods at one time on the first day of the first ovulation induction cycle of IVF-ET,from January 2020 to March 2023,were selected as the observation object,in which 104 infertile patients used the empirical evaluation method were the control group,other 108 infertile patients used quantitative evaluation method were the observation group.Score of knowledge related to injection,and score of injection operation on the next return day,and complications of injection on day of HCG injection within the same circle were compared between the two groups.Results In the observation group,the score of knowledge related to injection,the score of injection operation,and the score of 13 single in 20 items of injection related knowledge and injection operation were higher than those in the control group obviously(P<0.001).The complications of injection in the observation group was lower than that in the control group(P<0.05).Conclusion Compared to the empirical evaluation method,the quantitative evaluation method is more comprehensive and objective,can stimulate the positive learning attitude of infertile patient,who grasped of knowledge related to injection and injection operation more correct and standard,and improve the safety of self-injection for them.The single negative factors,used for preliminary diversion,has clinical practical value to judge whether an infertile patient has the self-injection capacity using prefilled injection pen.