摘要
目的:观察氟伐他汀联合氯吡格雷治疗脑梗死患者的效果。方法:选取2019年1月至2022年2月该院收治的96例脑梗死患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各48例。对照组采用氯吡格雷治疗,观察组在对照组基础上联合氟伐他汀治疗,比较两组临床疗效、治疗前后炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平、血脂指标[总胆固醇(TC)、三酰甘油(TG)]水平、神经功能缺损[美国国立卫生研究院卒中量表(NIHSS)]评分、日常生活能力[日常生活能力量表(ADL)]评分和不良反应发生率。结果:观察组治疗总有效率为95.83%(46/48),高于对照组的72.92%(35/48),差异有统计学意义(P<0.05);治疗后,两组CRP、IL-6、TC、TG水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组NIHSS评分均低于治疗前,且观察组低于对照组,两组ADL评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:氟伐他汀联合氯吡格雷治疗脑梗死患者可提高治疗总有效率和日常生活能力评分,改善炎性因子和血脂指标水平,降低神经功能缺损评分,效果优于单纯氯吡格雷治疗。
Objective:To observe effects of Fluvastatin combined with Clopidogrel in treatment of patients with cerebral infarction.Methods:A prospective study was conducted on 96 patients with cerebral infarction admitted to the hospital from January 2019 to February 2022.They were divided into control group and observation group according to the random number table method,48 cases in each.The control group was treated with Clopidogrel,while the observation group was treated with Fluvastatin on the basis of that of the control group.The clinical efficacy,the inflammatory factor levels[C-reactive protein(CRP),interleukin-6(IL-6)],the blood lipid index levels[total cholesterol(TC),triglyceride(TG)],the neurological deficits[National Institutes of Health stroke scale(NIHSS)]scores,the activities of daily living[activity of daily living scale(ADL)]score,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.83%(46/48),which was higher than 72.92%(35/48)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CRP,IL-6,TC and TG in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the NIHSS scores of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the ADL scores of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Fluvastatin combined with Clopidogrel in the treatment of the patients with cerebral infarction can improve the total effective rate and activities of daily living score,improve the levels of inflammatory factors and blood lipid indexes,and reduce the neurological deficit score.Moreover,it is superior to single Clopidogrel treatment.
作者
郭夏青
李郭飞
孙玉华
GUO Xiaqing;LI Guofei;SUN Yuhua(No.1 Neurology Department of Huaihe Hospital of Henan University,Kaifeng 475000 Henan,China)
出处
《中国民康医学》
2023年第15期18-20,24,共4页
Medical Journal of Chinese People’s Health
关键词
脑梗死
氯吡格雷
氟伐他汀
血脂
炎性因子
神经功能缺损
不良反应
Cerebral infarction
Clopidogrel
Fluvastatin
Blood lipid
Inflammatory factor
Neurological deficit
Adverse reaction