普萘洛尔联合甲巯咪唑治疗甲状腺功能亢进症患者的效果

Effect of Propranolol combined with Methimazole on patients with hyperthyroidism

目的:观察普萘洛尔联合甲巯咪唑治疗甲状腺功能亢进症(甲亢)患者的效果。方法:选取2020年1月至2021年12月该院收治的92例甲亢患者进行前瞻性研究,按随机数字表法将患者分为对照组和观察组各46例。对照组口服甲巯咪唑片治疗,观察组在对照组基础上联合盐酸普萘洛尔片治疗。比较两组临床疗效、治疗前后甲状腺功能指标[游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺激素(TSH)]水平、心率、生命质量[世界卫生组织生存质量测定简表(WHOQOL-BREF)]评分,以及不良反应发生率。结果:观察组治疗总有效率为91.30%(42/46),高于对照组的73.91%(34/46),差异有统计学意义(P<0.05);治疗后,观察组FT3、FT4水平及心率均低于对照组,TSH水平、WHOQOL-BREF评分均高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:普萘洛尔联合甲巯咪唑治疗甲亢患者可改善甲状腺功能,降低心率,提高患者生命质量,效果优于单用甲巯咪唑治疗。

Objective:To observe the effect of propranolol combined with methimazole on hyperthyroidism(hyperthyroidism).Methods:A prospective study was conducted on 92 patients with hyperthyroidism admitted to this hospital from January 2020 to December 2021.These patients were divided into control group and observation group according to the random number table method,46 cases in each group.The control group was treated with Methimazole tablets orally,while the observation group was treated with Propranolol hydrochloride tablets on the basis of that of the control group.The clinical efficacy,the levels of thyroid function indexes[free triiodothyronine(FT3),free thyroxine(FT4)and thyroid stimulating hormone(TSH)]before and after the treatment,the heart rate,the quality of life[World Health Organization quality of life-BREF(WHOQOL-BREF)]score,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 91.30%(42/46),which was higher than 73.91%(34/46)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FT3,FT4 and heart rate in the observation group were lower than those in the control group,the levels of TSH and WHOQOL-BREF scores were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Propranolol combined with Methimazole in the treatment of hyperthyroidism can improve thyroid function,reduce heart rate and improve the quality of life of patients,and the effect is better than that of methimazole alone.