组织液循环网络理论的验证和挑战

Verification and challenges of interstitial fluid circulatory network

经过近20年的探索,李宏义研究团队发现了人体和动物体内的大血管外膜、皮肤、神经和筋膜等结缔组织中存在着更加复杂的组织液流动网络,并揭示了其中血管外膜组织液流动网络的生理性调控机制。这些发现提示:不同于以心脏为中心的脉管网络中的血液循环,组织液在心肺等基质泵的作用下在全身结缔组织“基质-膜通道”系统中环绕驱动泵周而复始地连续流动,形成组织液循环网络;其功能之一是生理状态下的心脏搏动使得组织液向心性流动,而呼吸运动反向迟滞这种流动,从而增加器官或组织中的组织液灌注。本文综述了组织液循环网络理论的发展历程、现有研究结果、生理调控机制,并对该理论应用的未来发展方向进行了讨论。

After nearly 20 years of exploration,Li's team discovered that there are more complex interstitial fluid flow networks in connective tissues such as the adventitia of large blood vessels,skin,nerves and fascia in humans and animals,and revealed the physiological regulatory mechanism of the adventitial interstitial fluid flow network along the vasculature.These findings suggest that,unlike blood circulation in the heart-centered vascular network,these findings suggest that,under the actions of cardiac,pulmonary and other matrix pumps,interstitial fluid flows continuously around the driving pumps in the“interstitial matrix-membranes channel”system of connective tissues throughout the whole body,forming an interstitial fluid circulatory network.One of its functions is that the continuous heartbeats drive the interstitial fluid to flow centripetally under physiological conditions,while the respiratory movements retard such flow in reverse,thereby increasing the perfusion of interstitial fluid in the organs or tissues.This article reviews the development history,present research results,physiological regulatory mechanism of interstitial fluid circulatory network,and discusses the future development directions of the applications of this novel theory.